| Titre : | Vitamin D Status and the Risk of Cardiovascular Disease Death. (2009) |
| Auteurs : | Annamari KILKKINEN ; Antti ARO ; Markku HELIOVAARA ; Paul KNEKT ; Olli LMPIVAARA ; Jukka MARNIEMI ; Antti REUNANEN ; Harri RISSANEN ; National Institute for Health and Welfare. Helsinki. FIN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 170, n° 8, 2009) |
| Pagination : | 1032-1039 |
| Langues: | Anglais |
| Mots-clés : | Vitamine D ; Facteur risque ; Mortalité ; Mort ; Epidémiologie ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xCAD9G. Diffusion soumise à autorisation]. Accumulating evidence suggests that inadequate vitamin D levels may predispose people to chronic diseases. The authors aimed to investigate whether serum 25-hydroxyvitamin D (25 (OH) D) level predicts mortality from cardiovascular disease (CVD). The study was based on the Mini-Finland Health Survey and included 6,219 men and women aged>30 years who were free from CVD at baseline (1978-1980). During follow-up through 2006,640 coronary disease deaths and 293 cerebrovascular disease deaths were identified. Levels of 25 (OH) D were determined from serum collected at baseline. Cox's proportional hazards model was used to assess the association between 25 (OH) D and risk of CVD death. After adjustment for potential confounders, the hazard ratio for total CVD death was 0.76 (95% confidence interval (95% CI) : 0.60,0.95) for the highest quintile of 25 (OH) D level versus the lowest. The association was evident for cerebrovascular death (hazard ratio=0.48,95% CI : 0.31,0.75) but not coronary death (hazard ratio=0.91,95% CI : 0.70,1.18). A low vitamin D level may be associated with higher risk of a fatal CVD event, particularly cerebrovascular death. These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required. |
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