| Titre : | Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure : the French E3N cohort. (2009) |
| Auteurs : | KVASKOFF (Marina) : AUS. Queensland Institute of Medical Research. Cancer Control Group. Brisbane. ; Marie-Christine BOUTRON-RUAULT ; Francoise CLAVEL-CHAPELON ; Sylvie MESRINE ; Institut National de la Santé et de la Recherche Médicale. (I.N.S.E.R.M.). Eri 20. Ea 4045 and Institut Gustave Roussy. Villejuif. FRA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 38, n° 4, 2009) |
| Pagination : | 1143-1153 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Adulte ; Ultraviolet ; Sensibilité ; France ; Enquête cas témoin ; Epidémiologie ; Génétique ; Hormone ; Femme ; Homme ; Europe ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS tBlR0xJG. Diffusion soumise à autorisation]. Background. Endometriosis is an important women's health issue, however its aetiology remains unknown. An association between endometriosis and cutaneous melanoma was described, possibly explained through common genetic features. To further investigate this association, we assessed the link between phenotypic traits predisposing to melanoma and the risk of endometriosis. Methods. Using a case-control design, we analysed data from 97215 women of the Etude Epidémiologique auprès de femmes de l'Education Nationale study, a cohort of 98995 French women insured by a national health scheme mostly covering teachers, and aged 40-65 years at inclusion in 1990. Risk estimates were computed using unconditional logistic regression models. Results. After adjustment for potential confounding factors, there was a positive dose-effect relationship between risk of endometriosis (reported as surgically ascertained, n=4241) and skin sensitivity to sun exposure [moderate : odds ratio (OR) 1.09,95% confidence interval (CI) 0.99-1.19 ; high : OR 1.22 ; 95% CI 1.10-1.36 ; compared with none ; Ptrend<0.0001], number of naevi (few : OR 1.19,95% CI 1.05-1.35 ; many : OR 1.37,95% CI 1.21-1.55 ; very many : OR 1.59,95% CI 1.37-1.83 ; compared with none ; Ptrend<0.0001) and number of freckles (few : OR 1.08,95% CI 1.00-1.17 ; very many/many : OR 1.11,95% CI 1.03-1.20 ; compared with none ; Ptrend=0.005). Conclusion. This study is, to our knowledge, the first to report a positive dose-effect relationship between the risk of endometriosis and skin sensitivity to sun exposure, and number of naevi and freckles. These data suggest that endometriosis and melanoma may share some genetic features. |
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