| Titre : | Critical windows of exposure for arsenic-associated impairment of cognitive function in pre-school girls and boys : a population-based cohort study. (2011) |
| Auteurs : | J.D. HAMADANI ; S.E. ARIFEEN ; M. BOTTAI ; R. GARDNER ; HUDA (S.N.) : BGD. Institute of Nutrition and Food Science. Dhaka University. Dhaka. ; B. NERMELL ; S. SHIRAJI ; F. TOFAIL ; M. VAHTER |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 40, n° 6, 2011) |
| Pagination : | 1593-1604 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Arsenic ; Fonction cognitive ; Enfant 2 5 ans ; Enfant ; Femme ; Epidémiologie ; Population ; Femme enceinte ; Grossesse ; Mère ; Quotient intellectuel ; Sexe ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xn8DBs. Diffusion soumise à autorisation]. Background Exposure to arsenic through drinking water has been associated with impaired cognitive function in school-aged children in a few cross-sectional studies ; however, there is little information on critical windows of exposure. Methods We conducted a population-based longitudinal study in rural Bangladesh. We assessed the association of arsenic exposure, based on urinary arsenic (U-As ; twice during pregnancy and twice in childhood), with the development of about 1700 children at 5 years of age using Wechsler Pre-school and Primary Scale of Intelligence [intelligence quotient (IQ) ]. Results Median maternal U-As in pregnancy was 80 mug/l (10-90 percentiles : 25-400 mug/l). Children's urine contained 35 (12-155) mug/l and 51 (20-238) mug/l at 1.5 and 5 years, respectively. Using multivariable-adjusted regression analyses, controlling for all potential confounders and loss to follow-up, we found that verbal IQ (VIQ) and full scale IQ (FSIQ) were negatively associated with (log) U-As in girls. The associations were consistent, but somewhat stronger with concurrent arsenic exposure [VIQ : B =-2.4,95 % confidence interval (CI)=-3.8 to - 1.1 ; FSIQ : B =-1.4,95 % CI =-2.7 to - 0.1, n =817), compared with that at 1.5 years (VIQ : B =-0.85,95 % CI =-2.1 to 0.4 ; FSIQ : B =-0.74,95 % CI =-1.9 to 0.4, n =902), late gestation (VIQ : B =-1.52,95 % CI =-2.6 to - 0.4 ; FSIQ : B =-1.35,95 % CI =-2.4 to - 0.3, n =874) and early gestation (VIQ : B =-1.23,95 % CI =-2.4 to - 0.06 ; FSIQ : B =-0.92,95 % CI =-2.0 to - 0.2, n =833). In boys, U-As showed consistently low and non-significant associations with all IQ measures. An effect size calculation indicated that 100 mug/l U-As was associated with a decrement of 1-3 points in both VIQ and FSIQ in girls. Conclusion We found adverse effects of arsenic exposure on IQ in girls, but not boys, at 5 years of age. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact