| Titre : | The Effect of Including Cystatin C or Creatinine in a Cardiovascular Risk Model for Asymptomatic Individuals : The Multi-Ethnic Study of Atherosclerosis. (2011) |
| Auteurs : | Hiroki ITO ; Ramon DURAZO-ARVIZU ; David-Cjr GOFF ; . KIANG LIU ; Holly KRAMER ; Ivan-V PACOLD ; Michael-G SHILIPAK ; Russell-P TRACY ; Department of Preventive Medicine. Loyola University Medical Center. Maywood. IL. USA ; Division of Cardiology. Department of Medicine. Loyola University Medical Center. Maywood. IL. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 174, n° 8, 2011) |
| Pagination : | 949-957 |
| Langues: | Anglais |
| Mots-clés : | Artériosclérose ; Créatinine ; Facteur risque ; Modèle ; Homme ; Ethnie ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x8Fmpr. Diffusion soumise à autorisation]. The authors studied the incremental value of adding serum cystatin C or creatinine to the Framingham risk score variables (FRSVs) for the prediction of incident cardiovascular disease (CVD) among 6,653 adults without clinical CVD utilizing the Multi-Ethnic Study of Atherosclerosis (2000-2008). CVD events included coronary heart disease, heart failure, stroke, and peripheral arterial disease. Variables were transformed to yield optimal prediction of 6-year CVD events in sex-stratified models with FRSVs alone, FRSVs+cystatin C, and FRSVs+creatinine. Risk prediction in the 3 models was assessed by using the C statistic, and net reclassification improvement was calculated. The mean ages were 61.9 and 64.6 years for individuals with and without diabetes, respectively. After 6 years of follow-up, 447 (7.2%) CVD events occurred. In the total cohort, no significant change in the C statistic was noted with FRSVs+cystatin C and FRSVs+creatinine compared with FRSVs alone, and net reclassification improvement for CVD risk was extremely small and not significant with the addition of cystatin C or creatinine to FRSVs. Similar findings were noted after stratifying by baseline presence of diabetes. In conclusion, the addition of cystatin C or serum creatinine to FRSVs does not improve CVD risk prediction among adults without clinical CVD. |
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