| Titre : | Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies. (2010) |
| Auteurs : | Wolf-Peter SCHMIDT ; Kathy BAISLEY ; Mauricio-L Barreto ; Sophie BOISSON ; Sandy Cairncross ; Suzanne FILTEAU ; Bernd GENSER ; Department for Infectious and Tropical Diseases. London School of Hygiene and Tropical Medicine. GBR |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 64, n° 12, 2010) |
| Pagination : | 1074-1079 |
| Langues: | Anglais |
| Mots-clés : | Diarrhée ; Age ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS kAFlIR0x. Diffusion soumise à autorisation]. Background The validity of unblinded randomised trials testing interventions against diarrhoea is severely compromised by the potential for bias. Objective proxy markers for diarrhoea not relying on self-report are needed to assess the effect of interventions that cannot be blinded. Short-term changes in weight-for-age z-score (WAZ) may (due to catch-up growth) not be a clinically important marker for nutritional status. However, even a transient decrease in WAZ could indicate recent diarrhoea, and be interpreted as the effect of an intervention. Methods Using data from two large vitamin A trials from Ghana and Brazil, the immediate effect of the cumulative diarrhoea occurrence over 14 and 28 day time windows on WAZ was explored. Results A very strong linear association was found between the number of days with diarrhoea over the last 14-28 days and WAZ. In both trials, differences in diarrhoea between the trial arms were associated with corresponding differences in WAZ. Conclusion Repeated WAZ measures appear to be a suitable proxy marker for diarrhoea in children, but have disadvantages in terms of specificity and study power. |
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