| Titre : | Evaluation of a Novel Isotope Biomarker for Dietary Consumption of Sweets. (2010) |
| Auteurs : | Edwina-H YEUNG ; Cheryl-Am ANDERSON ; Josef CORESH ; A. HOPE JAHREN ; Melissa ISLAS ; Wen-Hong-linda KAO ; Rebecca KRAFT ; Christopher-D SAUDEK ; Department of Endocrinology and Metabolism. Johns Hopkins School of Medicine. Baltimore. MD. USA ; Department of General Internal Medicine. Johns Hopkins School of Medicine. Baltimore. MD. USA ; School of Earth and Ocean Science and Technology. University of Hawaii. Honolulu. HI. USA ; Welch Center for Prevention. Epidemiology. And Clinical Research. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 9, 2010) |
| Pagination : | 1045-1052 |
| Langues: | Anglais |
| Mots-clés : | Evaluation ; Régime alimentaire ; Alimentation ; Aliment ; Consommation ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xHmD89. Diffusion soumise à autorisation]. Carbon isotopic signatures ("delta13C") might reflect consumption of corn-and cane-based sweeteners. The authors hypothesized that the delta13C value of human serum is higher for individuals with high versus low intakes of corn-and cane-based sweeteners (measured as sweetened beverage intake). They conducted a cross-sectional study within the Atherosclerosis Risk in Communities Magnetic Resonance Imaging study (Maryland, 2005-2006). Diet was assessed by food frequency questionnaire, and blinded serum samples were assayed by natural abundance stable isotope mass spectroscopy. Studied were 186 participants (53% male ; mean age, 71 years ; mean body mass index, 30 kg/m2). Serum delta13C values for individuals with high sweetened beverage intakes were significantly higher than for those with low intakes (-19.15 vs. - 19.47, P<0.001). Serum delta13C value increased 0.20 for every serving/day of sweetened beverages (P<0.01). The association between sweetened beverages and serum delta13C value remained significant after adjustment for confounding by corn-based product intake (P<0.001). Serum delta13C values were also associated with waist circumference, body mass index, and waist-to-hip ratio. This study provides the first known evidence that the delta13C value of human serum differs between persons consuming low and high amounts of sweets. Within the proper framework, serum delta13C value could be developed into an objective biomarker promoting more reliable assessment of dietary sweets intake. |
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