Titre :
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Childhood Acute Leukemia, Early Common Infections, and Allergy : The ESCALE Study. (2010)
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Auteurs :
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Jérémie RUDANT ;
André BARUCHEL ;
Yves Bertrand ;
Pierre BORDIGONI ;
Jacqueline CLAVEL ;
Denis HEMON ;
Anne LAMBILLIOTTE ;
Geneviève MARGUERITTE ;
Francoise MECHINAUD ;
Florence MENEGAUX ;
Gérard MICHEL ;
Laurent ORSI ;
Arnaud Petit ;
Alain Robert ;
Julie TANDONNET ;
Environmental Epidemiology of Cancer. Cesp Centre for Research in Epidemiology and Population Health. U1018. Inserm. Villejuif. FRA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 172, n° 9, 2010)
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Pagination :
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1015-1027
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Langues:
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Anglais
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Mots-clés :
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Allergie
;
Infection
;
Enfant
;
Immunologie
;
Animal
;
Allaitement
;
Nourrisson
;
Epidémiologie
;
Homme
;
Immunopathologie
;
Cancer
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 8R0xDsq7. Diffusion soumise à autorisation]. This study investigated the role of factors considered related to early stimulation of the immune system in the etiology of childhood acute leukemia. The national registry-based case-control study ESCALE was carried out in France in 2003-2004. Population controls were frequency matched to cases on age and gender. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios were estimated using unconditional regression models adjusted for potential confounders. Included were 634 acute lymphoblastic leukemia cases, 86 acute myeloblastic leukemia cases, and 1,494 controls aged>=1 year. Negative associations were observed between acute lymphoblastic leukemia and birth order (P for trend
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