Résumé :
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[BDSP. Notice produite par INIST-CNRS DR0x8HHB. Diffusion soumise à autorisation]. Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus ; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31,2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT) n L (long) allele as compared with those with the (GT) n S (short) allele (odds ratio=1.12,95% confidence interval : 1.02,1.24 ; P=0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio=1.25,95% confidence interval : 1.04,1.50 ; P=0.02). Persons carrying longer (GT) n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.
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