| Titre : | Diet, Supplement Use, and Prostate Cancer Risk : Results From the Prostate Cancer Prevention Trial. (2010) |
| Auteurs : | Alan-R KRISTAL ; Demetrius ALBANES ; Kathryn-B Arnold ; Phyllis GOODMAN ; Marian-L NEUHOUSER ; Elizabeth-A PLATZ ; Ian-M THOMPSON |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 5, 2010) |
| Pagination : | 566-577 |
| Langues: | Anglais |
| Mots-clés : | Régime alimentaire ; Utilisation ; Facteur risque ; Risque ; Résultat ; Prévention santé ; Essai préventif ; Essai thérapeutique ; Procès ; Alimentation ; Supplémentation ; Nutrition ; Aliment ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS JBm8R0xn. Diffusion soumise à autorisation]. The authors examined nutritional risk factors for prostate cancer among 9,559 participants in the Prostate Cancer Prevention Trial (United States and Canada, 1994-2003). The presence or absence of cancer was determined by prostate biopsy, which was recommended during the trial because of an elevated prostate-specific antigen level or an abnormal digital rectal examination and was offered to all men at the trial's end. Nutrient intake was assessed using a food frequency questionnaire and a structured supplement-use questionnaire. Cancer was detected in 1,703 men ; 127 cancers were high-grade (Gleason score 8-10). There were no associations of any nutrient or supplement with prostate cancer risk overall. Risk of high-grade cancer was associated with high intake of polyunsaturated fats (quartile 4 vs. quartile 1 : odds ratio=2.41,95% confidence interval (CI) : 1.33,4.38). Dietary calcium was positively associated with low-grade cancer but inversely associated with high-grade cancer (for quartile 4 vs. quartile 1, odds ratios were 1.27 (95% CI : 1.02,1.57) and 0.43 (95% CI : 0.21,0.89), respectively). Neither dietary nor supplemental intakes of nutrients often suggested for prostate cancer prevention, including lycopene, long-chain n-3 fatty acids, vitamin D, vitamin E, and selenium, were significantly associated with cancer risk. High intake of n-6 fatty acids, through their effects on inflammation and oxidative stress, may increase prostate cancer risk. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact