| Titre : | Mortality in a Population Exposed to Dioxin after the Seveso, Italy, Accident in 1976 : 25 Years of Follow-Up. (2008) |
| Auteurs : | Dario CONSONNI ; Pier ALBERTO BERTAZZI ; CAVALIERI D'ORO (Luca) : ITA. Section of Epidemiology. Monza. ; Angela-C PESATORI ; Maurizia RUBAGOTTI ; Raffaella SINDACO ; ZOCCHETTI (Carlo) : ITA. Regional Epidemiological Office. Health Directorate. Lombardy Region. Milan. ; Epoca Research Center. Department of Occupational and Environmental Health. University of Milan. Milan. ITA ; Unit of Epidemiology. Department of Preventive Medicine. Fondazione Irccs Ospedale Maggiore Policlinico. Mangiagalli e Regina Elena. Milan. ITA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 167, n° 7, 2008) |
| Pagination : | 847-858 |
| Langues: | Anglais |
| Mots-clés : | Mortalité ; Epidémiologie ; Population ; Italie ; Accident chimique ; Accident ; Exposition professionnelle ; Carcinogène ; Environnement ; Industrie chimique ; Dioxine ; Homme ; Europe |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x8m9pI. Diffusion soumise à autorisation]. The Seveso accident in 1976 caused a large, populated area north of Milan, Italy, to be contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study, the authors followed up the exposed population for chronic effects ; this paper reports the results of the mortality follow-up extension for 1997-2001. The study cohort includes 278,108 subjects resident at the time of the accident or immigrating/born in the 10 years thereafter in three contaminated zones with decreasing TCDD soil levels (zone A, very high ; zone B, high ; zone R, low) and in a reference territory comprising surrounding, noncontaminated municipalities. Vital status and cause-of-death ascertainment were 99% complete. Adjusted rate ratios and 95% confidence intervals were calculated by using Poisson regression. Results confirmed previous findings of excesses of lymphatic and hematopoietic tissue neoplasms in zones A (six deaths ; rate ratio=2.23,95% confidence interval : 1.00,4.97) and B (28 deaths ; rate ratio=1.59,95% confidence interval : 1.09,2.33). These zones also showed increased mortality from circulatory diseases in the first years after the accident, from chronic obstructive pulmonary disease, and from diabetes mellitus among females. A toxic and carcinogenic risk to humans after high TCDD exposure is supported by the results of this study. |
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