| Titre : | Single Nucleotide Polymorphisms in Inflammation-related Genes and Mortality in a Community-based Cohort in Washington County, Maryland. (2008) |
| Auteurs : | Lisa GALLICCHIO ; Howard CHANG ; Dana-K CHRISTO ; Kathy-J HELZLSOUER ; Sandra-C HOFFMAN ; Han-Yao HUANG ; Ingo RUCZINSKI ; STRICKLAND (Paul) : USA. Department of Environmental Health Sciences. Johns Hopkins Bloomberg School of Public Health. Baltimore. MD. ; Lucy THUITA ; Prevention and Research Center. Weinberg Center for Women's Health and Medicine. Mercy Medical Center. Baltimore. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 167, n° 7, 2008) |
| Pagination : | 807-813 |
| Langues: | Anglais |
| Mots-clés : | Tumeur ; Inflammation ; Gène ; Homme ; Mortalité ; Epidémiologie ; Communauté ; Amérique ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS I8mlrR0x. Diffusion soumise à autorisation]. The purpose of this study was to examine the associations between single nucleotide polymorphisms (SNPs) in genes controlling inflammatory processes and mortality. Data were analyzed from 9,933 individuals who participated in two large community-based cohort studies conducted in Washington County, Maryland, in 1974 and 1989, designated "CLUE I" and "CLUE II," respectively. DNA from blood collected in 1989 was genotyped for 47 SNPs in 23 inflammation-related genes, including interferon-gamma (IFNy), lymphotoxin-alpha (LTalpha), tumor necrosis factor-a (TNFa), C-reactive protein (CRP), peroxisome proliferator-activated receptor (PPAR), and the human endothelial nitric oxide synthase (eNOS). All participants were followed from 1989 to the date of death or to June 20,2005. The results showed no observable patterns of association for the SNPs and the all-cause and cause-specific mortality outcomes, although statistically significant associations were observed between at least one mortality outcome and SNPs in eNOS (reference SNP (rs) 1799983), PPARG (rs4684847), CRP (rs2794521), IFNy (rs2069705), TNFalpha (rs1799964), and LTalpha (rs2229094). Additionally, three of the four examined CRP SNPs were strongly associated with CRP serum concentration among those with CRP measurements. The authors'findings from this community-based prospective cohort study suggest that the selected SNPs are not associated with overall or cause-specific death, although CRP genotypes may be associated with systemic inflammation. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact