| Titre : | Increased incidence of sporadic Creutzfeldt-Jakob disease in the age groups between 70 and 90 years in Belgium. (2006) |
| Auteurs : | B. VAN EVERBROECK ; P. CRAS ; DEPREZ (M.) : BEL. Laboratory of Neuropathology. University of Liège. Sart Tilman. Liège. ; GODFRAIND (C.) : BEL. Pathology Laboratory. Catholic University of Louvain. Brussels. ; J.J. Martin ; MICHOTTE (A.) : BEL. Department of Neuropathology. Academic hospital. Free University of Brussels. Brussels. ; QUOILIN (S.) : BEL. Institute of Public Health-Louis Pasteur. Brussels. ; SCIOT (R.) : BEL. Department of Pathology. Catholic University of Leuven. Leuven. ; University of Antwerp. Born-Bunge Institute. Antwerp. BEL |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 21, n° 6, 2006) |
| Pagination : | 443-447 |
| Langues: | Anglais |
| Mots-clés : | Infection ; Incidence ; Epidémiologie ; Maladie Creutzfeldt Jakob ; Examen complémentaire ; Personne âgée ; Homme ; Belgique ; Europe ; Diagnostic ; ESB ; Maladie dégénérative ; Système nerveux [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0x9TVJf. Diffusion soumise à autorisation]. From 1998 a prospective surveillance study of Creutzfeldt-Jakob disease (CJD) has been initiated in Belgium. In addition to epidemiological data, information on cerebrospinal fluid biomarkers, prion protein gene and brain neuropathology was collected. From 1-1-1998 to 31-12-2004,188 patients were referred to the surveillance system. In 85 patients a'definite'diagnosis of sporadic CJD (sCJD) could be made, whereas 26 patients remained'probable'We further identified two unrelated patients with an E200K mutation, and two patients with a seven octapeptide repeat insertion in one family. In one patient a familial history was noted but genetic analysis was not performed. In 72 patients different final diagnoses were made, Alzheimer's disease being the most frequent (N=20). The demographic parameters of the Belgian population were similar to those observed in the rest of Europe. We did notice a significantly increased age-specific incidence (>6/106/year) of sCJD patients between 70 and 90 years old in the period 2002-2004 compared to 1998-2001 and retrospectively obtained data (1990-1997, p<0.01). We undertook a detailed clinical and biochemical analysis to investigate this increase but could not identify any reason other than an increased vigilance for the diagnosis. In conclusion, our study identified that in the past sCJD may have been underestimated in patients over age 70 although these patients are both clinically and neurobiochemically similar to the general sCJD phenotype. |
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