| Titre : | Body Size, Recreational Physical Activity, and B-Cell Non-Hodgkin Lymphoma Risk Among Women in the California Teachers Study. (2009) |
| Auteurs : | . YANI LU ; Leslie BERNSTEIN ; Ellen-T CHANG ; Christina-A CLARKE ; Katherine-D HENDERSON ; Pamela-L Horn-Ross ; . HUIYAN MA ; PRESCOTT (Jennifer) : USA. Program in Molecular and Genetic Epidemiology. Harvard School of Public Health. Boston. MA. ; Jane SULLIVAN-HALLEY ; Giske URSIN ; Department of Preventive Medicine. Norris Comprehensive Cancer Center. University of Southern California Keck School of Medicine. Los Angeles. CA. USA ; Division of Cancer Etiology. Department of Population Science. City of Hope National Medical Center. Duarte. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 170, n° 10, 2009) |
| Pagination : | 1231-1240 |
| Langues: | Anglais |
| Mots-clés : | Taille corporelle ; Activité physique ; Facteur risque ; Risque ; Femme ; Homme ; Enseignant ; Hanche ; Epidémiologie ; Amérique ; Anthropométrie ; Amérique du Nord ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS Etk88R0x. Diffusion soumise à autorisation]. Nutritional status and physical activity are known to alter immune function, which may be relevant to lymphoma-genesis. The authors examined body size measurements and recreational physical activity in relation to risk of B-cell non-Hodgkin lymphoma (NHL) in the prospective California Teachers Study. Between 1995 and 2007,574 women were diagnosed with incident B-cell NHL among 121,216 eligible women aged 22-84 years at cohort entry. Multivariable-adjusted relative risks and 95% confidence intervals were estimated by fitting Cox proportional hazards models for all B-cell NHL combined and for the 3 most common subtypes : diffuse large B-cell lymphoma, follicular lymphoma, and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Height was positively associated with risk of all B-cell NHLs (for>1.70 vs. 1.61-1.65 m, relative risk=1.50,95% confidence interval : 1.16,1.96) and chronic lymphocytic leukemia/small lymphocytic lymphoma (relative risk=1.93,95% confidence interval : 1.09,3.41). Weight and body mass index at age 18 years were positive predictors of B-cell NHL risk overall. These findings indicate that greater height, which may reflect genetics, early life immune function, infectious exposures, nutrition, or growth hormone levels, may play a role in NHL etiology. Adiposity at age 18 years may be more relevant to NHL etiology than that in later life. |
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