| Titre : | Prediction of Incident Stroke Events Based on Retinal Vessel Caliber : A Systematic Review and Individual-Participant Meta-Analysis. (2009) |
| Auteurs : | Kevin MCGEECHAN ; Monique-Mb BRETELER ; DE JONG (Paulus-Tvm) : NLD. Department of Ophthalmology. Academic Medical Center. Amsterdam. ; Les IRWIG ; . JIE JIN WANG ; Ronald Klein ; Barbara-Ek Klein ; Gerald LIEW ; Petra MACASKILL ; Paul MITCHELL ; Jonathan SHAW ; Johannes-R VINGERLING ; Jacqueline-Cm WITTEMAN ; WONG (Tien-Y) : SGP. Singapore Eye Research Institute. Yong Loo Lin School of Medicine. National University of Singapore. ; Paul ZIMMET ; Baker Idi Heart and Diabetes Institute. Melbourne Victoria. AUS ; Department of Epidemiology and Biostatistics. Erasmus Medical Center. Rotterdam. NLD ; Department of Ophthalmology and Visual Sciences. University of Wisconsin School of Medicine and Public Health. Madison. WI. USA ; Department of Ophthalmology. Erasmus Medical Center. Rotterdam. NLD ; Screening and Test Evaluation Program. School of Public Health. University of Sydney. Sydney New South Wales. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 170, n° 11, 2009) |
| Pagination : | 1323-1332 |
| Langues: | Anglais |
| Mots-clés : | Accident cérébrovasculaire ; Incidence ; Rétine ; Vaisseau ; Homme ; Participation ; Facteur risque ; Risque ; Epidémiologie ; Oeil ; Appareil cardiovasculaire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xkkmkH. Diffusion soumise à autorisation]. The caliber of the retinal vessels has been shown to be associated with stroke events. However, the consistency and magnitude of association, and the changes in predicted risk independent of traditional risk factors, are unclear. To determine the association between retinal vessel caliber and the risk of stroke events, the investigators combined individual data from 20,798 people, who were free of stroke at baseline, in 6 cohort studies identified from a search of the Medline (National Library of Medicine, Bethesda, Maryland) and EMBASE (Elsevier B.V., Amsterdam, the Netherlands) databases. During follow-up of 5-12 years, 945 (4.5%) incident stroke events were recorded. Wider retinal venular caliber predicted stroke (pooled hazard ratio=1.15,95% confidence interval : 1.05,1.25 per 20-mum increase in caliber), but the caliber of retinal arterioles was not associated with stroke (pooled hazard ratio=1.00,95% confidence interval : 0.92,1.08). There was weak evidence of heterogeneity in the hazard ratio for retinal venular caliber, which may be attributable to differences in follow-up strategies across studies. Inclusion of retinal venular caliber in prediction models containing traditional stroke risk factors reassigned 10.1% of people at intermediate risk into different, mostly lower, risk categories. |
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