Titre : | Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes in a Chinese Population. (2009) |
Auteurs : | FANGFANG SONG (.) : CHN. Department of Epidemiology and Biostatistics. Tianjin Medical University Cancer Hospital and Institute. Tianjin. ; HU (Frank-B) : USA. Department of Nutrition. Harvard School of Public Health. Boston. MA. ; . LIEGANG LIU ; MUXUN ZHANG (.) : CHN. Department of Internal Medicine. The Institute of Endocrinology. Tongji Hospital. Tongji Medical College. Huazhong University of Science and Technology. Wuhan. ; . NIANHONG YANG ; . PING YAO ; . XIANGYANG LI ; . XIUFA SUN ; Department of Nutrition and Food Hygiene. Moe Key Laboratory of Environment and Health. School of Public Health. Tongji Medical College. Huazhong University of Science and Technology. Wuhan. CHN |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 170, n° 6, 2009) |
Pagination : | 747-756 |
Langues: | Anglais |
Mots-clés : | Association ; Gène ; Génétique ; Homme ; Chine ; Epidémiologie ; Enzyme ; Asie ; Glande endocrine [pathologie] ; Effet promoteur |
Résumé : | [BDSP. Notice produite par INIST-CNRS qER0xtDF. Diffusion soumise à autorisation]. The authors aimed to determine whether 2 functional polymorphisms in the heme oxygenase-1 (HO-1) gene promoter are associated with type 2 diabetes mellitus (T2DM). A Chinese case-control study involving 1,103 newly diagnosed T2DM patients, 371 patients with impaired glucose regulation (IGR), and 1,615 controls was performed (December 2004-December 2007). A (GT) n microsatellite polymorphism and a single nucleotide polymorphism, T (-413) A, were genotyped, and their functional relevance was evaluated by examining the level of HO-1 protein expression. For the (GT) n microsatellite polymorphism, genotypes with the L (GT) n allele (>25 GT repeats) were associated with increased odds of IGR or T2DM compared with the S/S genotype ( |