| Titre : | Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes in a Chinese Population. (2009) |
| Auteurs : | FANGFANG SONG (.) : CHN. Department of Epidemiology and Biostatistics. Tianjin Medical University Cancer Hospital and Institute. Tianjin. ; HU (Frank-B) : USA. Department of Nutrition. Harvard School of Public Health. Boston. MA. ; . LIEGANG LIU ; MUXUN ZHANG (.) : CHN. Department of Internal Medicine. The Institute of Endocrinology. Tongji Hospital. Tongji Medical College. Huazhong University of Science and Technology. Wuhan. ; . NIANHONG YANG ; . PING YAO ; . XIANGYANG LI ; . XIUFA SUN ; Department of Nutrition and Food Hygiene. Moe Key Laboratory of Environment and Health. School of Public Health. Tongji Medical College. Huazhong University of Science and Technology. Wuhan. CHN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 170, n° 6, 2009) |
| Pagination : | 747-756 |
| Langues: | Anglais |
| Mots-clés : | Association ; Gène ; Génétique ; Homme ; Chine ; Epidémiologie ; Enzyme ; Asie ; Glande endocrine [pathologie] ; Effet promoteur |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qER0xtDF. Diffusion soumise à autorisation]. The authors aimed to determine whether 2 functional polymorphisms in the heme oxygenase-1 (HO-1) gene promoter are associated with type 2 diabetes mellitus (T2DM). A Chinese case-control study involving 1,103 newly diagnosed T2DM patients, 371 patients with impaired glucose regulation (IGR), and 1,615 controls was performed (December 2004-December 2007). A (GT) n microsatellite polymorphism and a single nucleotide polymorphism, T (-413) A, were genotyped, and their functional relevance was evaluated by examining the level of HO-1 protein expression. For the (GT) n microsatellite polymorphism, genotypes with the L (GT) n allele (>25 GT repeats) were associated with increased odds of IGR or T2DM compared with the S/S genotype (<25 GT repeats) (S/L genotype : odds ratio (OR)=1.35, P=0.048 ; UL genotype : OR=1.65, P=0.006). Subsequent haplotype analysis showed that haplotype TL contributed to increased odds of IGR or T2DM compared with haplotype TS (OR=1.56, P=0.003). In functional analyses, HO-1 expression level was significantly reduced in persons with IGR and T2DM carrying the UL (GT) n genotype compared with persons with the S/S genotype. Further haplotype combination assay confirmed the functional dominance of the (GT) n microsatellite polymorphism over the T (-413) A single nucleotide polymorphism. These results support an association between the HO-1 (GT) n microsatellite polymorphism, HO-1 expression levels, and the odds of T2DM. |
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