| Titre : | Human Papillomavirus Testing for Cervical Cancer Screening : Results From a 6-Year Prospective Study in Rural China. (2009) |
| Auteurs : | Ju-Fang SHI ; Jerome-L BELINSON ; . FENG CHEN ; . JING LI ; Jun-Fei MA ; Qin-Jing PAN ; Robert-G PRETORIUS ; You-Lin QIAO ; Jennifer-S Smith ; . WANG XIANG ; . XUN ZHANG ; Wen-Hua ZHANG ; Fang-Hui ZHAO ; Department of Cancer Epidemiology. Cancer Institute. Hospital. Chinese Academy of Medical Sciences. Peking Union Medical College. Beijing. CHN ; Department of Gynecology and Obstetrics. Cleveland Clinic Foundation. Cleveland. OH. USA ; Department of Pathology. Cancer Institute. Hospital. Chinese Academy of Medical Sciences. Peking Union Medical College. Beijing. CHN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 170, n° 6, 2009) |
| Pagination : | 708-716 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Homme ; Dépistage ; Résultat ; Etude prospective ; Milieu rural ; Chine ; Prévention santé ; Epidémiologie ; Virus ; Asie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 7kBR0xll. Diffusion soumise à autorisation]. Long-term follow-up evaluations of cervical screening approaches are limited in low-resource areas. This prospective study assessed the risk of future cervical intraepithelial neoplasia grade 2 or worse (ClN2+) associated with baseline human papillomavirus (HPV) and cytologic status. In rural China, 1,997 women were screened with 6 screening tests, including colposcopic evaluations, and underwent biopsies in 1999. In December 2005,1,612 women with cervical intraepithelial neoplasia grade 1 or less at baseline were rescreened by visual inspection, liquid-based cytology, and HPV-DNA testing. All women underwent colposcopy at follow-up, with biopsies taken from women with visually apparent lesions or cytologic abnormalities. Twenty women developed incident ClN2+The crude relative risk of CIN2+for baseline HPV-positive women was 52 (95% confidence interval : 12.1,222.5). The crude relative risk of ClN2+was 167 (95% confidence interval : 21.9,1,265) for baseline and follow-up repeatedly HPV-positive women compared with repeatedly HPV-negative women. Among 1,374 baseline HPV-negative women, 2 and no incident ClN2+cases were detected in baseline cytologically normal and abnormal subgroups, respectively. Among 238 baseline HPV-positive women, 6 of 18 incident cases of ClN2+developed in the cytologically normal group. This study demonstrates that a single oncogenic HPV-DNA test is more effective than cytology in predicting future ClN2+status. |
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