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Rise in seroprevalence of herpes simplex virus type 1 among highly sexual active homosexual men and an increasing association between herpes simplex virus type 2 and HIV over time (1984-2003).

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Titre :	Rise in seroprevalence of herpes simplex virus type 1 among highly sexual active homosexual men and an increasing association between herpes simplex virus type 2 and HIV over time (1984-2003). (2007)
Auteurs :	Colette SMIT ; BERKHOUT (Ben) : NLD. Department of Human Retrovirology. Academic Medical Center. Amsterdam. ; COUTINHO (Roel) : NLD. Center for Infectious Diseases Control. Bilthoven. ; Nicole-Htm DUKERS ; MINDEL (Adrian) : AUS. Sexually Transmitted Infections Research Centre. University of Sydney. Marian Villa. Westmead Hospital. Westmead. ; Christiaan PFROMMER ; Joke SPAARGAREN ; TAYLOR (Janette) : AUS. Institute for Pathology and Medical Research (Icpmr). Sydney. ; Center for Infection and Immunity Amsterdam. Academic Medical Center. Amsterdam. NLD ; Cluster Infectious diseases. Health Service of Amsterdam. Stichting Hiv monitoring. (A.Z.A.M.S.T.E.R.D.A.M.). NLD ; Public Health Laboratory of the Health Service. Amsterdam. NLD
Type de document :	Article
Dans :	European journal of epidemiology (vol. 22, n° 12, 2007)
Pagination :	937-944
Langues:	Anglais
Mots-clés :	Sérologie ; Prévalence ; Epidémiologie ; Virose ; Homosexualité ; Homme ; Association ; Sida ; VIH ; Infection ; Virus ; Rétrovirus ; Immunopathologie
Résumé :	[BDSP. Notice produite par INIST-CNRS Ee7nR0x9. Diffusion soumise à autorisation]. Objectives : Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) are both highly prevalent. The rate of genital HSV-1 transmission is reportedly increasing over time. HSV-2 is considered to be an important risk factor for HIV transmission. We therefore studied changes in the HSV-1 and HSV-2 prevalence in a large cohort of men who have sex with men (MSM) over a 20-year time period. Methods : Among 1847 HIV-infected and HIV-uninfected MSM participating in the Amsterdam Cohort Studies, seroprevalence of HSV-1 and HSV-2 was determined and prevalence rate ratios (PRR) and 95% confidence intervals were calculated. Results : Between 1984 and 2003 the HSV-1 and HSV-2 prevalence decreased among HIV-uninfected MSM (P<0.001), but remained stable among HIV-infected MSM. HSV-1 prevalence increased among men with at least 200 sexual partners over lifetime (PRR : 1.49, P<0.001). The association between HIV infection and HSV-2 became stronger over time (PRR : 3.45, P<0.001). Conclusions : Seroprevalence of HSV-1 and HSV-2 remained high among HIV infected MSM from 1984 to 2003. The association of HIV and HSV-2 increased during the HIV epidemic. Since the proportion of sexual transmission of HSV-1 is rising, it is important to study the potential role of HSV-1 as risk factor for HIV acquisition.