| Titre : | Adult Body Size, Hormone Receptor Status, and Premenopausal Breast Cancer Risk in a Multiethnic Population : The San Francisco Bay Area Breast Cancer Study. (2011) |
| Auteurs : | Esther-M JOHN ; Pamela-L Horn-Ross ; Jocelyn KOO ; PHIPPS (Amanda-I) : USA. Division of Public Health Sciences. Fred Hutchinson Cancer Research Center. Seattle. WA. ; Meera SANGARAMOORTHY ; Division of Epidemiology. Department of Health Research and Policy. Stanford University School of Medicine. And Stanford Cancer Center. Stanford. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 173, n° 2, 2011) |
| Pagination : | 201-216 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Jeune adulte ; Taille corporelle ; Sein ; Facteur risque ; Risque ; Ethnie ; Population ; Femme ; Epidémiologie ; Homme ; Amérique ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qR0xs8I9. Diffusion soumise à autorisation]. Large body size has been associated with a reduced risk of premenopausal breast cancer in non-Hispanic white women. Data on other racial/ethnic populations are limited. The authors examined the association between premenopausal breast cancer risk and adult body size in 672 cases and 808 controls aged>35 years from a population-based case-control study conducted in 1995-2004 in the San Francisco Bay Area (Hispanics : 375 cases, 483 controls ; African Americans : 154 cases, 160 controls ; non-Hispanic whites : 143 cases, 165 controls). Multivariate adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. Height was associated with increased breast cancer risk (highest vs. lowest quartile : odds ratio=1.77,95% confidence interval : 1.23,2.53 ; Ptrend<0.01) ; the association did not vary by hormone receptor status or race/ethnicity. Body mass index (measured as weight (kg) divided by height (m) squared) was inversely associated with risk in all 3 racial/ethnic groups, but only for estrogen receptor-and progesterone receptor-positive tumors (body mass index>30 vs.<25 : odds ratio=0.42 ; 95% confidence interval : 0.29,0.61). Other body size measures (current weight, body build, adult weight gain, young adult weight and body mass index, waist circumference, and waist-to-height ratio) were similarly inversely associated with risk of estrogen receptor-and progesterone receptor-positive breast cancer but not estrogen receptor-and progesterone receptor-negative disease. Despite racial/ethnic differences in body size, inverse associations were similar across the 3 racial/ethnic groups when stratified by hormone receptor status. |
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