| Titre : | Long-term Statin Use and the Risk of Gallstone Disease : A Population-based Case-Control Study. (2011) |
| Auteurs : | Rune ERICHSEN ; Trine FROSLEV ; Timothy-L LASH ; Lars PEDERSEN ; Henrik-Toft SORENSEN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 173, n° 2, 2011) |
| Pagination : | 162-170 |
| Langues: | Anglais |
| Mots-clés : | Long terme ; Facteur risque ; Risque ; Vésicule biliaire ; Pathologie ; Population ; Enquête cas témoin ; Epidémiologie ; Voie biliaire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS HR0xs9lk. Diffusion soumise à autorisation]. Most gallstones originate from cholesterol-supersaturated bile. Statins inhibit hepatic cholesterol biosynthesis and therefore may reduce the risk of gallstone disease. Population-based evidence, however, is sparse. Thus, the authors conducted a population-based case-control study using medical databases from northern Denmark (1.7 million inhabitants) to identify 32,494 cases of gallstones occurring between 1996 and 2008 and to identify age-sex-and county-matched population controls for each case. Cases and their matched controls who were exposed to lipid-lowering drugs were categorized as current users if their last prescription was redeemed<90 days before the case's diagnosis date ; otherwise, they were categorized as former users. Conditional logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals for gallstone disease in patients treated with lipid-lowering drugs. In current users, the adjusted odds ratios associating statin use with the occurrence of gallstone disease were 1.17 (95% confidence interval (CI) : 1.06,1.30) for those who had 1-4 prescriptions, 0.89 (95% CI : 0.80,0.97) for those who had 5-19 prescriptions, and 0.76 (95% CI : 0.69,0.84) for those who had>=20 total prescriptions. In former users, the corresponding adjusted odds ratios were 1.24 (95% CI : 1.11,1.39), 0.97 (95% CI : 0.86,1.10), and 0.79 (95% CI : 0.64,0.97), respectively. The use of other lipid-lowering drugs showed no similar association. |
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