Titre :
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Response to influenza vaccine in people with non-protective HI antibody titers. (2006)
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Auteurs :
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Vincenzo BALDO ;
Tatjana BALDOVIN ;
FLOREANI (Annarosa) : ITA. Department of Surgical and Gastroenterological Sciences. University of Padova. Padova. ;
Michele MINUZZO ;
Renzo TRIVELLO ;
University of Padua. Institute of Hygiene. Department of Environmental Medicine and Public Health. Padova. ITA
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 21, n° 11, 2006)
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Pagination :
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843-845
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Langues:
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Anglais
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Mots-clés :
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Vaccin
;
Grippe
;
Virose
;
Infection
;
Homme
;
Anticorps
;
Prévention santé
;
Epidémiologie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS q9gR0x12. Diffusion soumise à autorisation]. The purpose of the study was to determine which factors correlate directly with response to vaccination in such a group of subjects with non-protective HI antibody titers before vaccination. Two vaccines were used, a subunit virus vaccine adjuvanted with MF59 and a split virus vaccine. The analysis indicated that immunization with vaccine adjuvanted with MF59 was an independent variable for immune response against A/H3N2 (OR : 3.51 ; 95% CI : 1.81-6.79) and B (OR : 2.31 ; 95% CI : 1.37-3.89). The results suggest that antibody response to vaccine is satisfactory in elderly people previously lacking a protective antibody titer, and that the adjuvanted vaccine reveals a better immunogenicity.
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