| Titre : | Exposure to famine during gestation, size at birth, and blood pressure at age 59 y : evidence from the dutch famine. (2006) |
| Auteurs : | STEIN (Aryeh-D) : USA. Rollins School of Public Health. Emory University. Atlanta. GA. ; L.H. LUMEY ; VAN DER PAL-DE BRUIN (Karin) : NLD. Tno Quality of Life. Leiden. ; Patricia-A ZYBERT |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 21, n° 10, 2006) |
| Pagination : | 759-765 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Malnutrition ; Hypertension artérielle ; Nutrition ; Alimentation ; Grossesse ; Taille corporelle ; Pression artérielle ; Europe ; Carence alimentaire ; Homme ; Epidémiologie ; Appareil circulatoire [pathologie] ; Maladie nutrition ; Pays Bas |
| Résumé : | [BDSP. Notice produite par INIST-CNRS us1GR0xa. Diffusion soumise à autorisation]. We compared blood pressure of individuals (mean age 59 y) born in western Holland between January 1945 and March 1946 (mothers exposed to the Dutch Famine before or during gestation ; n=359) to blood pressure of unexposed individuals born before or conceived after the famine (n=299) or same-sex siblings of subjects in series 1 or 2 (n=313). Mean (SD) systolic and diastolic blood pressure were 140.3 (20.3) and 85.8 (11.0) mmHg, respectively ; prevalence of hypertension (prior diagnosis of hypertension or with measured systolic/diastolic blood pressure above 140/90 mmHg) was 61.8%. Birth weight was inversely related to systolic (-4.14 mmHg per kg ; 95% confidence interval (CI) - 7.24, - 1.03 ; p<0.01) and diastolic (-2.09 mmHg per kg ; 95% CI - 3.77, - 0.41 ; p<0.05) blood pressure and to the prevalence of hypertension (odds ratio 0.67 per kg, 95% CI : 0.49,0.93) (all age-and sex-adjusted). Any famine exposure of at least 10 weeks duration was associated with elevated systolic (2.77 mmHg ; 95% CI 0.25,5.30 ; p<0.05) and diastolic (1.27 mmHg ; 95% CI-0.13,2.66 ; p=0.08) blood pressure and with hypertension prevalence (odds ratio 1.44 ; 95% CI 1.04,2.00 ; p<0.05) in age-and sex-adjusted models. Exposure to famine during gestation may predispose to the development of hypertension in middle age. |
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