| Titre : | Racial Differences in the Association Between Night Shift Work and Melatonin Levels Among Women. (2013) |
| Auteurs : | Parveen BHATTI ; Scott DAVIS ; Dana-K MIRICK ; Program in Epidemiology. Public Health Sciences Division. Fred Hutchinson Cancer Research Center. Seattle. WA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 5, 2013) |
| Pagination : | 388-393 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Ethnie ; Epidémiologie ; Race ; Etude comparée ; Association ; Travail nocturne ; Femme ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 879R0x9p. Diffusion soumise à autorisation]. Reduced suppression of melatonin in response to working the night shift among people of Asian ancestry has been suggested as a possible explanation for the null results observed in a recent analysis of shift work and breast cancer risk in a Chinese cohort. The authors analyzed the impact of Asian versus white race on previously reported differences in urinary 6-sulfatoxymelatonin levels in a 2003-2008 study in Seattle, Washington, of female health-care workers that exclusively worked night or day shifts. A total of 225 white and 51 Asian participants were included in the analysis. Although 6-sulfatoxymelatonin levels were affected by night shift work in both racial groups, Asian night shift workers consistently showed 6-sulfatoxymelatonin levels that were closer to levels in day shift workers than did white night shift workers. Furthermore, differences in 6-sulfatoxymelatonin levels between white and Asian night shift workers relative to day shift workers were statistically significant in every instance (P<0.05). These results suggest that Asians may be better able to maintain a "normal" circadian pattern of melatonin production compared with whites and suggest a biological mechanism by which Asian night shift workers may be at a reduced risk of cancer. |
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