| Titre : | Endometrial Cancer Risk Factors by 2 Main Histologic Subtypes The NIH-AARP Diet and Health Study. (2013) |
| Auteurs : | Hannah-P YANG ; Louise-A BRINTON ; Ashley-S FELIX ; Gretchen-L GIERACH ; Marc-J GUNTER ; Albert HOLLENBECK ; Yikyung PARK ; Mark-E SHERMAN ; Britton TRABERT ; Nicolas WENTZENSEN ; Hormonal and Reproductive Epidemiology Branch. Division of Cancer Epidemiology and Genetics. National Cancer Institute. Nih. Department of Health and Human Services. Bethesda. MD. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 2, 2013) |
| Pagination : | 142-151 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Régime alimentaire ; Etude prospective ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS l9rB9R0x. Diffusion soumise à autorisation]. On the basis of clinical and pathologic criteria, endometrial carcinoma has been distinguished as Types I (mainly endometrioid) and II (nonendometrioid). Limited data suggest that these subtypes have different risk factor profiles. The authors prospectively evaluated risk factors for Types I (n=1,312) and II (n=138) incident endometrial carcinoma among 114,409 women in the National Institutes of Health (NIH) - AARP Diet and Health Study (1995-2006). For individual risk factors, relative risks were estimated with Cox regression by subtype, and Pheterogeneity was assessed in case-case comparisons with Type I as the referent. Stronger relations for Type I versus Type II tumors were seen for menopausal hormone therapy use (relative risk (RR) of 1.18 vs.0.84 ; Pheterogeneity=0.01) and body mass index of>=30 vs.<30 kg/m2 (RR of 2.93 vs.1.83 ; Pheterogeneity=0.001). Stronger relations for Type II versus Type I tumors were observed for being black versus white (RR of 2.18 vs.0.66 ; Pheterogeneity=0.0004) and having a family history of breast cancer (RR of 1.93 vs.0.80 ; Pheterogeneity=0.002). Other risk factor associations were similar by subtype. In conclusion, the authors noted different risk factor associations for Types I and II endometrial carcinomas, supporting the etiologic heterogeneity of these tumors. Because of the limited number of Type II cancers, additional evaluation of risk factors will benefit from consortial efforts. |
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