| Titre : | Younger Siblings, C-Reactive Protein, and Risk of Age-Related Macular Degeneration. (2013) |
| Auteurs : | Amy-C COHN ; Paul-N BAIRD ; BUSIJA (Lucy) : AUS. Melbourne EpiCentre. Department of Medicine. University of Melbourne. Melbourne. ; Peter-N DIMITROV ; Robyn-H GUYMER ; Lyndell-L LIM ; Liubov-D ROBMAN ; Mary VARSAMIDIS ; The Centre for Eye Research Australia. University of Melbourne. And Royal Victorian Eye and Ear Hospital. Melbourne. AUS |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 9, 2013) |
| Pagination : | 933-943 |
| Langues: | Anglais |
| Mots-clés : | Fratrie ; Facteur risque ; Risque ; Inflammation ; Exposition ; Epidémiologie ; Rétinopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS ok9o9R0x. Diffusion soumise à autorisation]. In this study, we examined the relationship between exposure to siblings and 1) the risk of age-related macular degeneration (AMD) and 2) C-reactive protein levels. We retrospectively analyzed pooled cross-sectional data from 2 studies : the Cardiovascular Health and Age-Related Maculopathy Study (2001-2002) and the Age-Related Maculopathy Statin Study (2004-2006). Associations between number of siblings and AMD were assessed by using multinomial logistic regression. Associations between number of siblings and C-reactive protein levels were examined by using a generalized linear model for gamma distribution. A higher number of younger siblings was associated with significantly lower odds of early AMD in those with a family history of AMD (odds ratio=0.2,95% confidence interval : 0.1,0.8) (P=0.022) but was unrelated to AMD for those who had no family history of the disease (odds ratio=1.0,95% confidence interval : 0.9,1.2) (P=0.874). A higher number of younger siblings correlated with lower C-reactive protein levels (bêta=-0.19,95% confidence interval : - 0.38, - 0.01) (P=0.036). This supports the theory that immune modulation contributes to AMD pathogenesis and suggests that exposure to younger siblings might be protective when there is a family history of AMD. |
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