| Titre : | Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillation. (2013) |
| Auteurs : | Jouni KARPPI ; ANTERO LAUKKANEN (Jari) : FIN. Department of Internal Medicine. Lapland Central Hospital. Rovaniemi. ; HEIKKI MAKIKALLIO (Timo) : FIN. Division of Cardiology. Department of Internal Medicine. University of Oulu. Oulu. ; Sudhir KURL ; Kimmo RONKAINEN ; Department of Medicine. Institute of Public Health and Clinical Nutrition. University of Eastern Finland. Kuopio. FIN |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 28, n° 1, 2013) |
| Pagination : | 45-53 |
| Langues: | Anglais |
| Mots-clés : | Plasma sanguin ; Risque cumulé ; Facteur associé ; Association ; Facteur risque ; Risque ; Personne âgée ; Population ; Prévention santé ; Epidémiologie ; Homme ; Cardiopathie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS B8qIDR0x. Diffusion soumise à autorisation]. Systemic inflammation, oxidative stress, and atrial fibrosis are identified as the main mechanisms for atrial fibrillation (AF). Antioxidant micronutrients may have antiarrhythmic benefit in humans. We studied whether plasma carotenoids are related to the risk of AF in elderly subjects. The study population consisted of 1,847 Finnish subjects (620 women and 1,227 men) aged 61-82 years from the Kuopio Ischaemic Heart Disease Risk Factor study cohort. Plasma concentrations of carotenoids were measured by high-performance liquid chromatography. The multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of plasma carotenoids were analyzed using the Cox proportional hazard's model. During a median follow-up of 2.8 years a total of 105 subjects developed incident AF. The HRs of AF among subjects with levels in the highest through the lowest tertile after adjustment for age, examination year, gender, systolic blood pressure, smoking, alcohol consumption, education, diabetes, use of antihypertensive medication, congestive heart failure, recurrent AF, prevalent coronary heart disease and baseline prevalence of myocardial infarction were 1.70 (95% CI : 1.01-2.86, p=0.047) for lutein, 1.99 (95% CI : 1.14-3.48, p=0.016) for zeaxanthin. Risk of AF was borderline significant for bêta-carotene (HR=1.69,95% CI : 1.00-2.87, p=0.050). Results remained unchanged, when season was added to the multivariable model. Lycopene, bêta-cryptoxanthin, alpha-carotene and total carotenoids were not associated with the risk of AF. Results of the present study suggest that low plasma concentrations of lutein and zeaxanthin were associated with an increased risk of AF in elderly population. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact