| Titre : | Two Epstein-Barr Virus-Related Serologic Antibody Tests in Nasopharyngeal Carcinoma Screening : Results From the Initial Phase of a Cluster Randomized Controlled Trial in Southern China. (2013) |
| Auteurs : | . ZHIWEI LIU ; Su-Mei CAO ; Wei-Min CHENG ; . FANG FANG ; . FENG CHEN ; Ming-Huang HONG ; Qi-Hong HUANG ; Ming-Fang JI ; Wei-Hua JIA ; Er-Hong LIN ; Wan-Li LIU ; Hao-Yuan MO ; . QING LIU ; Kuang-Rong WEI ; . WEI LING ; . WEIMIN YE ; Biao-Hua WU ; . XIANG GUO ; . XIAO LIN ; Shang-Hang XIE ; You-Ye YANG ; Yuan-Long YU ; . YUE LIU ; Yi-Xin ZENG ; Cancer Research Institute of Zhongshan. Zhongshan Guangdong province. CHN ; Department of Epidemiology. Cancer Prevention Center. State Key Laboratory of Oncology in Southern China. Sun Yat-sen University Cancer Center. Guangzhou. CHN ; Department of Experimental Research. State Key Laboratory of Oncology in Southern China. Sun Yat-sen University Cancer Center. Guangzhou. CHN ; Department of Nasopharyngeal Carcinoma. State Key Laboratory of Oncology in Southern China. Sun Yat-sen University Cancer Center. Guangzhou. CHN ; Sihui Cancer Institute. Sihui Guangdong province. CHN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 3, 2013) |
| Pagination : | 242-250 |
| Langues: | Anglais |
| Mots-clés : | Anticorps ; Dépistage ; Résultat ; Randomisation ; Essai préventif ; Essai thérapeutique ; Chine ; Diagnostic ; Prévention santé ; Epidémiologie ; Virus ; Asie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS rnR0xk7G. Diffusion soumise à autorisation]. A nasopharyngeal carcinoma (NPC) mass screening trial using a combination of immunoglobulin A antibodies to Epstein-Barr virus capsid antigen and nuclear antigen-1 by enzyme-linked immunosorbent assay in addition to indirect mirror examination in the nasopharynx and/or lymphatic palpation (IMLP) was conducted in southern China. Cantonese aged 30-59 years residing in 2 cities randomly selected by cluster sampling, Sihui and Zhongshan, were invited to participate in this screening from May 2008 through May 2010. Participants were offered fiberoptic endoscopy examination and/or pathologic biopsy if their serologic tests reached our predefined level of high risk or if results from the physical examination indicated possible cancer (i.e., were IMLP positive). A total of 28,688 individuals were voluntarily screened in the initial round. The overall NPC detection rate was 0.14% (41/28,688) with an early diagnosis rate of 68.3% (28/41) during the first year of follow-up. Thirty-eight of 41 cases (92.7%) were detected among the high-risk group, and 7 of 41 cases (17.1%) were detected among the IMLP-positive group. The 2 Epstein-Barr virus serologic tests by enzyme-linked immunosorbent assay could be a feasible alternative for NPC screening in endemic areas. Further follow-up is needed to examine whether screening has an effect on decreasing mortality from NPC in these areas. |
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