| Titre : | Hepatitis B vaccination in women healthcare workers : A seroepidemiological survey. (2007) |
| Auteurs : | C. LOCQUET ; D. CHOUDAT ; J.L. MARANDE ; G. VIDAL-TRECAN |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 22, n° 2, 2007) |
| Pagination : | 113-119 |
| Langues: | Anglais |
| Mots-clés : | Hépatite virale B ; Virose ; Infection ; Prévention santé ; Vaccination ; Femme ; Homme ; Sérologie ; Profession santé ; Epidémiologie ; Enquête épidémiologique ; Enquête ; Surveillance ; Vaccin ; Appareil digestif [pathologie] ; Foie [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS k7y9R0x8. Diffusion soumise à autorisation]. Objective : To assess the concentration and kinetics of antibody response after hepatitis B vaccination among women healthcare workers. Design. Longitudinal retrospective seroepidemiological survey among women vaccinated against hepatitis B working in a university hospital and followed-up in an occupational health department. A structured form was used to collect socio-demographic characteristics, clinical data, age at vaccination, vaccination schedule, measurement of antibodies to hepatitis B surface antigen (anti-HBs antibody). Subjects were considered seronegative against hepatitis B when anti-HBs antibody concentration was less than 10 mIU/ml. Setting. A 1260-bed general hospital in Paris, France. Participants. All women healthcare workers visiting the occupational health department between January 1997 1st and December 2000 31st and who had a measurement of anti-HBs antibody. Results : Irrespective of the age at the primary vaccination, 810 (92%) women were seropositive (anti-HBs antibody>10 mIU/ml). Only 22 women (4.5%) vaccinated before 26 years of age were seronegative, against 46 (13.2%) vaccinated after 25 years of age (p<0.001). Seven years after vaccination, 78% of women were still seropositive. An inadequate vaccination schedule (adjusted hazard ratio (HR), 3.0 ; 95% confidence interval [CI], 1.6-5.5) and an age greater than 25 years at primary vaccination (HR, 2.6 ; 95% CI, 1.5-4.4) were associated with being seronegative against hepatitis B. Conclusions. Despite vaccination, some women healthcare workers were seronegative against hepatitis B virus. Vaccinating early in the career of a health-care worker using an adequate schedule seems key-elements to guarantee an anti-HBs measurement>=10 mIU/ml. |
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