| Titre : | Is 2,3,5-pyrroletricarboxylic acid in hair a better risk indicator for melanoma than traditional epidemiologic measures for skin phenotype ? (2007) |
| Auteurs : | Stefano ROSSO ; Daniela BAIZI ; Cesare BARBERA ; Maria-Dolores CHIRLAQUE ; Gabriella FABBROCINI ; Rüdiger GREINERT ; Carmela LAURIA ; Dora LORIA ; Mariette MERCIER ; Ana MIRANDA ; Adoracion NIETO ; Anne OSTERLIND ; Maria-José SANCHEZ ; Hélène Sancho-Garnier ; Roberto ZANETTI ; Marina ZOCCOLA ; Helios Working Group. INC ; Oncology Prevention Center. Piedmont Cancer Registry. Turin. ITA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 10, 2007) |
| Pagination : | 1170-1177 |
| Langues: | Anglais |
| Mots-clés : | Acide ; Cheveu ; Poil ; Facteur risque ; Risque ; Indicateur risque ; Indicateur ; Epidémiologie ; Peau ; Infrarouge ; Homme ; Cancer ; Examen complémentaire |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 6H92WR0x. Diffusion soumise à autorisation]. This study aims to assess type of melanin as a risk indicator for skin tumors, in a sample of melanoma cases and controls within a larger multicenter study (Helios 2), held in Europe and South America in 2001-2002. In each case and control, the melanin content in hair was assessed by three methods : 1) the amount of 2,3,5-pyrroletricarboxylic acid (PTCA) ; 2) the absorbance ratio with ultraviolet spectroscopy ; and 3) the spectra of near-infrared spectroscopy. Statistical analysis was performed in a Bayesian setting, defining priors for confounders and effect modifiers from the larger study data set. Subjects with values of PTCA of less than 85 ng/mg carried an increased risk (26 vs. seven discordant pairs : odds ratio=4.4,95% confidence interval : 1.52,14.54), adjusted by hair color, eye color, and number of nevi (n=>40). The absorbance ratio showed a weaker and nonsignificant odds ratio of 1.5. After correction by misclassification, near-infrared spectroscopy was associated with an odds ratio of 2.3 (95% confidence interval : 1.36,4.22). The amount of PTCA is thus a strong and independent risk indicator for melanoma. Incorporating PTCA determination into epidemiologic studies is therefore recommended. |
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