| Titre : | Oral contraceptives, reproductive factors, and risk of colorectal cancer among women in a prospective cohort study. (2007) |
| Auteurs : | Jennifer LIN ; BURING (Julie-E) : USA. Department of Ambulatory Care and Prevention. Harvard Medical School. Boston. MA. ; Nancy-R COOK ; I-Min LEE ; MANSON (Joann-E) : USA. Channing Laboratory. Department of Medicine. Brigham and Women's Hospital and Harvard Medical School. Boston. MA. ; Shumin-M ZHANG |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 7, 2007) |
| Pagination : | 794-801 |
| Langues: | Anglais |
| Mots-clés : | Contraception hormonale ; Contraception ; Reproduction ; Facteur risque ; Femme ; Homme ; Etude prospective ; Contraceptif oral ; Contraceptif ; Voie orale ; Hormone ; Ménopause ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS AlZIR0xL. Diffusion soumise à autorisation]. Previous findings on the associations between oral contraceptive (OC) use and reproductive factors and risk of colorectal cancer have been inconclusive. The authors evaluated associations of OC use and reproductive factors (including parity, age at first birth, age at menarche, and age at menopause) with risk of colorectal cancer among women in a large-scale prospective cohort study. The analysis included 39,680 participants in the Women's Health Study who had usable information on ever use of OCs and potential risk factors for colorectal cancer. Relative risks and 95% confidence intervals were estimated from Cox proportional hazards regression models. All p values were two-sided. During an average of 11 years of follow-up (1992-2004), 267 incident cases of colorectal cancer were documented. Ever use of OCs was associated with a lower risk of colorectal cancer (relative risk=0.67,95% confidence interval : 0.50,0.89). Women who had used OCs for 6 months-<3 years had a relative risk of 0.61 (95% confidence interval : 0.40,0.94) relative to never users, with little additional decreased risk being seen with longer duration of use (p for multivariate trend=0.09). No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact