| Titre : | Birth weight and subsequent risk of type 2 diabetes : A meta-analysis. (2007) |
| Auteurs : | Thomas HARDER ; Joachim-W DUDENHAUSEN ; Andreas PLAGEMANN ; Elke RODEKAMP ; Karen SCHELLONG ; Charité University Medicine Berlin. Obstetrics Clinic. "Experimental Obstetrics" Research Group. Berlin. DEU |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 8, 2007) |
| Pagination : | 849-857 |
| Langues: | Anglais |
| Mots-clés : | Poids naissance ; Evolution ; Facteur risque ; Risque ; Epidémiologie ; Homme ; Glande endocrine [pathologie] ; Métabolisme [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS A9CoR0xV. Diffusion soumise à autorisation]. The "small baby syndrome hypothesis" suggests that an inverse linear relation exists between birth weight and risk of type 2 diabetes. The authors conducted a meta-analysis to examine this association. They included studies that reported odds ratios and 95% confidence intervals (or data with which to calculate them) for the association of type 2 diabetes with birth weight. Fourteen studies involving a total of 132,180 persons were identified. Low birth weight (<2,500 g), as compared with a birth weight of>=2,500 g, was associated with increased risk of type 2 diabetes (odds ratio (OR)=1.32,95% confidence interval (Cl) : 1.06,1.64). High birth weight (>4,000 g), as compared with a birth weight of<4,000 g, was associated with increased risk to the same extent (OR=1.27,95% Cl : 1.01,1.59). Pooled estimates increased further when normal birth weight (2,500-4,000 g) was used as the reference category (low birth weight : OR=1.47,95% Cl : 1.26,1.72 ; high birth weight : OR=1.36,95% Cl : 1.07,1.73). Meta-regression and categorical analyses showed a U-shaped relation between birth weight and diabetes risk. These findings indicate that there exists a relation between birth weight and later-life risk of type 2 diabetes which is not linearly inverse but U-shaped. |
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