| Titre : | Parental age and risk of childhood cancers : a population-based cohort study from Sweden. (2006) |
| Auteurs : | Benjamin-H YIP ; Kamila CZENE ; Yudi PAWITAN |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 35, n° 6, 2006) |
| Pagination : | 1495-1503 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Facteur risque ; Epidémiologie ; Age ; Parent ; Suède ; Europe ; Enfant ; Homme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS bPCvR0xy. Diffusion soumise à autorisation]. Background : Frequent germ line cells mutations were previously demonstrated to be associated with aging. This suggests a higher incidence of childhood cancer among children of older parents. A population-based cohort study of parental ages and other prenatal risk factors for five main childhood cancers was performed with the use of a linkage between several national-based registries. Methods : In total, about 4.3 million children with their parents, born between 1961 and 2000, were included in the study. Multivariate Poisson regression was used to obtain the incidence rate ratios (IRR) and 95% confidence interval (CI). Children<5 years of age and children 5-14 years of age were analysed independently. Results : There was no significant result for children 5-14 years of age. For children<5 years of age, maternal age were associated with elevated risk of retinoblastoma (oldest age group's IRR=2.39,95% CI=1.17-4.85) and leukaemia (oldest age group's IRR=1.44,95% CI=1.01-2.05). Paternal age was significantly associated with leukaemia (oldest age group's IRR=1.31,95% CI=1.04-1.66). For central nervous system cancer, the effect of paternal age was found to be significant (oldest age group's IRR=1.69,95% CI=1.21-2.35) when maternal age was included in the analysis. Conclusion : Our findings indicate that advanced parental age might be associated with an increased risk of early childhood cancers. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact