| Titre : | Risk of Total and Aggressive Prostate Cancer and Pesticide Use in the Agricultural Health Study. (2013) |
| Auteurs : | Stella KOUTROS ; Michael-Cr ALAVANJA ; Gabriella ANDREOTTI ; Laura-E BEANE FREEMAN ; Aaron BLAIR ; Curt-T DELLAVALLE ; HELTSHE (Sonya-L) : USA. Department of Pediatrics. School of Medicine. University of Washington. Seattle. WA. ; Jane-A HOPPIN ; Kathryn HUGHES BARRY ; Jay-H LUBIN ; LYNCH (Charles-F) : USA. College of Public Health. University of Iowa. Iowa City. IA. ; Dale-P SANDLER |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 1, Janvier 2013) |
| Pagination : | 59-74 |
| Langues: | Anglais |
| Mots-clés : | Facteur risque ; Risque ; Pesticide ; Utilisation ; Agriculture ; Exposition ; Epidémiologie ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS nkH8R0xJ. Diffusion soumise à autorisation]. Because pesticides may operate through different mechanisms, the authors studied the risk of prostate cancer associated with specific pesticides in the Agricultural Health Study (1993-2007). With 1,962 incident cases, including 919 aggressive prostate cancers among 54,412 applicators, this is the largest study to date. Rate ratios and 95% confidence intervals were calculated by using Poisson regression to evaluate lifetime use of 48 pesticides and prostate cancer incidence. Three organophosphate insecticides were significantly associated with aggressive prostate cancer : fonofos (rate ratio (RR) for the highest quartile of exposure (Q4) vs. nonexposed=1.63,95% confidence interval (CI) : 1.22,2.17 ; Ptrend<0.001) ; malathion (RR for Q4 vs. nonexposed=1.43,95% CI : 1.08,1.88 ; Ptrend=0.04) ; and terbufos (RR for Q4 vs. nonexposed=1.29,95% CI : 1.02,1.64 ; Ptrend=0.03). The organochlorine insecticide aldrin was also associated with increased risk of aggressive prostate cancer (RR for Q4 vs. nonexposed=1.49,95% CI : 1.03,2.18 ; Ptrend=0.02). This analysis has overcome several limitations of previous studies with the inclusion of a large number of cases with relevant exposure and detailed information on use of specific pesticides at 2 points in time. Furthermore, this is the first time specific pesticides are implicated as risk factors for aggressive prostate cancer. |
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