| Titre : | Coffee, Tea, and Fatal Oral/Pharyngeal Cancer in a Large Prospective US Cohort. (2013) |
| Auteurs : | Janet-S HILDEBRAND ; CHEN (Amy-Y) : USA. Department of Otolaryngology-Head and Neck Surgery. Emory University. Atlanta. GA. ; Susan-M GAPSTUR ; Mia-M GAUDET ; HAYES (Richard-B) : USA. Department of Environmental Medicine. New York University Medical Center. New York. NY. ; Marjorie-L MCCULLOUGH ; Alpa-V PATEL |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 1, Janvier 2013) |
| Pagination : | 50-58 |
| Langues: | Anglais |
| Mots-clés : | Café ; Thé ; Cavité buccale ; Etude prospective ; Caféine ; Epidémiologie ; Mortalité ; Pharynx ; Médicament psychotrope ; Amérique ; Stomatologie ; Cancer ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS CmR0xsC8. Diffusion soumise à autorisation]. Epidemiologic studies suggest that coffee intake is associated with reduced risk of oral/pharyngeal cancer. The authors examined associations of caffeinated coffee, decaffeinated coffee, and tea intake with fatal oral/pharyngeal cancer in the Cancer Prevention Study II, a prospective US cohort study begun in 1982 by the American Cancer Society. Among 968,432 men and women who were cancer free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up. Cox proportional hazards regression was used to estimate multivariable-adjusted relative risk. Intake of>4 cups/day of caffeinated coffee was associated with a 49% lower risk of oral/pharyngeal cancer death relative to no/occasional coffee intake (relative risk=0.51,95% confidence interval : 0.40,0.64) (1 cup/day=237 ml). A dose-related decline in relative risk was observed with each single cup/day consumed (Ptrend<0.001). The association was not modified by sex, smoking status, or alcohol use. An inverse association for>2 cups/day of decaffeinated coffee intake was suggested (relative risk=0.61,95% confidence interval : 0.37,1.01). No association was found for tea drinking. In this large prospective study, caffeinated coffee intake was inversely associated with oral/pharyngeal cancer mortality. Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers. |
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