| Titre : | Association Between Prediagnostic Biomarkers of Inflammation and Endothelial Function and Cancer Risk : A Nested Case-Control Study. (2013) |
| Auteurs : | Mathilde Touvier ; Namanjeet AHLUWALIA ; Nathalie CHARNAUX ; CZERNICHOW (Sebastien) : FRA. Department of Nutrition. Ambroise Pare Hospital. Inserm U1018. Epidemiology and Public Health Center (Cesp). University Versailles St-Quentin. Boulogne Billancourt. ; Leopold FEZEU ; Pilar GALAN ; Serge Hercberg ; Chantal Julia ; Paule LATINO-MARTEL ; Caroline Méjean ; Angela SUTTON ; Biochemistry Department. Jean Verdier Hospital. Bondy. FRA ; Cardiovascular and Bioengineering Team. Inserm U698. Paris 13 University. Bobigny. FRA ; Nutritional Epidemiology Unit. National Institute for Health and Medical Research. Inserm U557. National Institute for Food and Agricultural Research. (I.N.R.A.). National Academy for Engineering Studies. (C.N.A.M.). Paris 13 University. Bobigny. FRA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 1, Janvier 2013) |
| Pagination : | 3-13 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Risque cumulé ; Facteur associé ; Association ; Inflammation ; Facteur risque ; Risque ; Enquête cas témoin ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS GA7trR0x. Diffusion soumise à autorisation]. Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors'objective was to prospectively examine the relations between these biomarkers and cancer risk. A nested case-control study was designed within the Supplementation en Vitamines et Mineraux Antioxydants (SU. VI. MAX) Study, a nationwide French cohort study, to include all first primary incident cancers diagnosed between 1994 and 2007 (n=512). Cases were matched with randomly selected controls (n=1,024) on sex, age (in 2-year strata), body mass index (weight (kg)/height (m) 2 ;<25 vs.>=25), and SU. VI. MAX intervention group. Conditional logistic regression was used to study the associations between prediagnostic levels of high-sensitivity C-reactive protein (hs-CRP), adiponectin, leptin, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble E-selectin, and monocyte chemoattractant protein 1 and cancer risk. All statistical tests were 2-sided. Plasma sICAM-1 level was positively associated with breast cancer risk (for quartile 4 vs. quartile 1, multivariate odds ratio (OR)=1.86,95% confidence interval (CI) : 1.06,3.26 ; Ptrend=0.048). Plasma hs-CRP level was positively associated with prostate cancer risk (for quartile 4 vs. quartile 1, multivariate OR=3.04,95% CI : 1.28,7.23 ; Ptrend=0.03). These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated with increased prostate and breast cancer risk, respectively. |
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