Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x0z4PP. Diffusion soumise à autorisation]. Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH) - AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and 95% confidence intervals were estimated by Cox regression. During up to 6 years of follow-up (n=293,888), the authors identified 10,180 total prostate cancer cases (8,754 nonadvanced, 1,426 advanced, and 178 fatal cases). Total and supplemental calcium were unrelated to total and nonadvanced prostate cancer. However, a statistically nonsignificant positive association with total calcium was observed for advanced (>2,000 vs. 500-<750 mg/day : relative risk (RR)=1.25,95% confidence interval (Cl) : 0.91,1.71 ; ptrend=0.06) and fatal (>1,000 vs. 500-<750 mg/day : RR=1.39,95% Cl : 0.92,2.09 ; ptrend=0.10) prostate cancer. Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer (>2 vs. zero servings/day : RR=1.23,95% Cl : 0.99,1.54 ; ptrend=0.01). In contrast, calcium from nondairy foods was associated with lower risk of nonadvanced prostate cancer (>600 vs.<250 mg/day : RR=0.82,95% Cl : 0.68,0.99 ; ptrend=0.04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk.
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