| Titre : | Is radiographic vertebral fracture a risk factor for mortality ? (2007) |
| Auteurs : | TRONE (Daniel-W) : USA. Graduate School of Public Health. San Diego State University. San Diego. CA. ; Elizabeth BARRETT-CONNOR ; Donna KRITZ-SILVERSTEIN ; Denise-G VON MUHLEN ; Deborah-L WINGARD ; Division of Epidemiology. Department of Family and Preventive Medicine. University of California. San Diego. La Jolla. CA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 10, 2007) |
| Pagination : | 1191-1197 |
| Langues: | Anglais |
| Mots-clés : | Rachis ; Fracture ; Radiographie ; Vertèbre ; Ostéoporose ; Facteur risque ; Mortalité ; Epidémiologie ; Os ; Homme ; Examen complémentaire ; Radiodiagnostic ; Traumatisme |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 1bYR0xgK. Diffusion soumise à autorisation]. Clinical fractures predict increased mortality risk, but few studies report mortality based on prevalent radiographically defined vertebral fracture. This study examined whether radiographically defined vertebral fracture is a risk factor for mortality in older adults. The 1,580 participants in California (631 men, 949 women) were aged>50 years in 1992-1996. Lateral spine radiographs, and information about medical history and behaviors, were obtained. Overall, 55 (8.7%) men and 123 (13%) women had at least one prevalent fracture at baseline ; of these, 48 women and 14 men had two or more. Over 7.6 years, 460 participants died, 27.6% without and 41.0% with prevalent fractures (p<0.001). Prevalent vertebral fracture was not associated with all-cause mortality in both sexes combined (adjusted hazard ratio=1.09,95% confidence interval : 0.84,1.42) or sex-specific analyses (women : adjusted hazard ratio=1.15,95% confidence interval : 0.83,1.59 ; men : adjusted hazard ratio=0.89,95% confidence interval : 0.55,1.46). However, women with two or more prevalent fractures had increased risk of all-cause mortality (adjusted hazard ratio=1.56,95% confidence interval : 1.01,2.40 ; p=0.04). Women with any prevalent vertebral fractures also had increased mortality risk from "other" causes (adjusted hazard ratio=1.59,95% confidence interval : 1.03,2.45 ; p=0.04) but not cardiovascular disease or cancer. A single radiographic vertebral fracture is not a risk for mortality in older women ; larger, longer studies of men and those with two or more radiographic vertebral fractures are needed. |
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