| Titre : | Whole grains and risk of pancreatic cancer in a large population-based case-control study in the San Francisco bay area, California. (2007) |
| Auteurs : | CHAN (June-M) : USA. Department of Urology. School of Medicine. University of California. San Francisco. San Francisco. CA. ; . FURONG WANG ; HOLLY (Elizabeth-A) : USA. Department of Health Research and Policy. School of Medicine. Stanford University. Stanford. CA. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 166, n° 10, 2007) |
| Pagination : | 1174-1185 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Facteur risque ; Risque ; Enquête cas témoin ; Epidémiologie ; Céréale ; Régime alimentaire ; Enquête épidémiologique ; Enquête ; Surveillance ; Fibre alimentaire ; Amérique ; Cancer ; Alimentation ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 6T6R0xP1. Diffusion soumise à autorisation]. Epidemiologic data suggest that consumption of whole-grain products may be inversely associated with risk of pancreatic cancer. Grain intake was examined in a population-based case-control study of pancreatic cancer in the San Francisco Bay Area (1995-1999). A 131-item semiquantitative food frequency questionnaire was administered to 532 cases and 1,701 controls. Odds ratios and 95% confidence intervals were computed as estimates of relative risk. Persons who consumed>2 servings of whole grains daily had a lower risk of pancreatic cancer than persons who consumed<1 serving/day (odds ratio (OR)=0.60,95% confidence interval (Cl) : 0.31,1.2 ; trend-p=0.04). Similar results were observed for brown rice (OR=0.72,95% Cl : 0.44,1.2 ; trend-p=0.01) and tortillas (OR=0.56,95% Cl : 0.35,0.89 ; trend-p=0.02). Consumption of doughnuts (>2 servings/week vs.<1 serving/month) conferred increased risk (OR=1.8,95% Cl : 1.2,2.7 ; trend-p=0.003). Consumption of cooked breakfast cereals (>2 servings/week vs.<1 serving/month) was positively associated with risk (for oatmeal/oat bran, OR=1.3,95% Cl : 1.0,1.7 ; for other cooked breakfast cereals, OR=2.1,95% Cl : 1.4,3.3). Dietary fiber was inversely associated with risk (for highest quartile vs. lowest, OR=0.65,95% Cl : 0.47,0.89 ; trend-p=0.02). These data provide some support for the hypothesis that consuming more whole-grain or high-fiber foods may reduce the risk of pancreatic cancer. Refined grains were not associated with risk. |
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