| Titre : | AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families. (2007) |
| Auteurs : | YANG (Yan-Jun) : CHN. College of Life Science. Jinzhong University. Jinzhong Shanxi. ; Xiang-Ding CHEN ; DENG (Hong-Wen) : USA. Department of Orthopedic Surgery. School of Medicine. University of Missouri-Kansas City. Kansas City. MO. ; . HUI SHEN ; De-Ke JIANG ; Shu-Feng LEI ; Ji-Rong Long ; WANG (Yan-Bo) : CHN. College of Shu Da. Hunan Normal University. Changsha Hunan. ; Su-Mei XIAO ; . YUAN CHEN ; Lan-Juan ZHAO ; Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education. College of Life Sciences. Hunan Normal University. Changsha Hunan. CHN ; Osteoporosis Research Center and Department of Biomedical Sciences. Creighton University. Omaha. NE. USA |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 22, n° 8, 2007) |
| Pagination : | 527-532 |
| Langues: | Anglais |
| Mots-clés : | Association ; Famille ; Homme ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS BxJDR0x7. Diffusion soumise à autorisation]. Purpose To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation. Methods A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT). Results Significant within-family associations were obtained for spine BMD at both of studied markers (P=0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P=0.008 at the NlaIII locus) (P=0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association. Conclusions These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact