| Titre : | Aflatoxin exposure in utero causes growth faltering in Gambian infants. (2007) |
| Auteurs : | Paul-C TURNER ; Andrew-C COLLINSON ; Yunyun GONG ; Andrew-J HALL ; Andrew-M PRENTICE ; Christopher-P WILD ; . YIN BUN CHEUNG ; Infectious Disease Epidemiology Unit. London School of Hygiene & Tropical Medicine. University of London. London. GBR ; Molecular Epidemiology Unit. Centre for Epidemiology and Biostatistics. Leeds Institute of Genetics. Health and Therapeutics. Faculty of Medicine and Health. University of Leeds. Leeds. GBR ; Mrc International Nutrition Group. Public Health Nutrition Unit. London School of Hygiene & Tropical Medicine. London. GBR ; Mrc Keneba. Mrc laboratories. Fajara. GMB |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 36, n° 5, 2007) |
| Pagination : | 1119-1125 |
| Langues: | Anglais |
| Mots-clés : | Exposition ; Foetus ; Facteur ; Croissance ; Nourrisson ; Gambie ; Toxine ; Homme ; Afrique |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 22mR0xcP. Diffusion soumise à autorisation]. Background : Growth faltering in West African children has previously been associated with dietary exposure to aflatoxins, particularly upon weaning. However, in animal studies in utero exposure to low levels of aflatoxin also results in growth faltering. Objective : This study investigated the effect of in utero aflatoxin exposure on infant growth in the first year of life in The Gambia. Methods : Height and weight were measured for 138 infants at birth and at regular monthly intervals for one year. Aflatoxin-albumin (AF-alb) adduct level was measured in maternal blood during pregnancy, in cord blood and in infants at age 16 weeks. Results : The geometric mean AF-alb levels were 40.4pg/mg (range 4.8-260.8 pg/mg), 10.1pg/mg (range 5.0-189.6pg/mg) and 8.7pg/mg (range 5.0-30.2 pg/mg) in maternal, cord and infant blood, respectively. AF-alb in maternal blood was a strong predictor of both weight (P=0.012) and height (P=0.044) gain, with lower gain in those with higher exposure. A reduction of maternal AF-alb from 110pg/mg to 10 pg/mg would lead to a 0.8kg increase in weight and 2cm increase in height within the first year of life. Conclusions : This study shows a strong effect of maternal aflatoxin exposure during pregnancy on growth in the first year of life and thus extends earlier observations of an association between aflatoxin exposure during infancy and growth faltering. The findings imply value in targeting intervention strategies at early life exposures. |
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