| Titre : | Could ultraviolet B irradiance and vitamin D be associated with lower incidence rates of lung cancer ? (2008) |
| Auteurs : | S.B. MOHR ; C.F. GARLAND ; F.C. GARLAND ; E.D. GORHAM ; GRANT (W.B.) : USA. Sunlight and Nutrition Research Center. San Francisco. CA. |
| Type de document : | Article |
| Dans : | Journal of epidemiology and community health (vol. 62, n° 1, 2008) |
| Pagination : | 69-74 |
| Langues: | Anglais |
| Mots-clés : | Vitamine D ; Ultraviolet ; Association ; Incidence ; Taux ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS gR0x0SSY. Diffusion soumise à autorisation]. Background : This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence. Methods : The association of latitude and UVB irradiance with age-adjusted incidence rates of lung cancer in 111 countries was investigated. Independent associations with UVB irradiance, cloud cover, anthropogenic aerosols, and cigarette smoking, were assessed using multiple regression. Results : Latitude was positively related to incidence rates in men (R2=0.55, p<0.01) and women (fl2=0.36, p<0.01). In men, cigarette consumption (p<0.001) was positively related to risk, whereas UVB irradiance was inversely associated (p=0.003). There were positive associations with UVB absorbers, in particular cloud cover (p=0.05) and aerosol optical depth (p=0.005). The R2 for the model was 0.78 (p<0.001). UVB irradiance was also inversely associated with incidence rates in women (p=0.0002), whereas cigarette consumption (p<0.001), total cloud cover (p=0.02) and aerosol optical depth (p=0.005) were positively associated. The R2 for the model was 0.77 (p<0.001).). Conclusions : Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries. |
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