| Titre : | Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort. (2008) |
| Auteurs : | Rachael-Z STOLZENBERG-SOLOMON ; Kenneth ADAMS ; Albert HOLLENBECK ; Michael LEITZMANN ; Dominique-S MICHAUD ; Catherine SCHAIRER ; Arthur SCHATZKIN ; Debra-T SILVERMAN |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 167, n° 5, 2008) |
| Pagination : | 586-597 |
| Langues: | Anglais |
| Mots-clés : | Homme ; Activité physique ; Régime alimentaire ; Tabagisme ; Tabac ; Epidémiologie ; Amérique ; Cancer ; Alimentation ; Anthropométrie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS lR0x4a1g. Diffusion soumise à autorisation]. Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of<18.5 kg/m2 were excluded. A subcohort (n=302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000,654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of>35 had a 45% greater pancreatic cancer risk (95% confidence interval (Cl) : 1.04,2.02 ; ptrend=0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI>35 : hazard ratio=1.70,95% Cl : 1.14,2.53 ; ptrend=0.004) but not recent smokers (pinteraction=0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile : hazard ratio=2.53,95% Cl : 1.13,5.65 ; ptrend=0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer. |
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