| Titre : | Serum osteoprotegerin levels are related to height loss : The Tromso Study. (2011) |
| Auteurs : | JORGENSEN (Lone) : NOR. Department of Health and Care Sciences. University of Tromso. Tromso. ; BROX (Jan) : NOR. Department of Medical Biology. University of Tromso. Tromso. ; John-Bjarne Hansen ; JACOBSEN (Bjarne-K) : NOR. Department of Community Medicine. University of Tromso. Tromso. ; MATHIESEN (Ellisiv) : NOR. Department of Clinical Medicine. University of Tromso. Tromso. ; Anders VIK ; Center for Atherothrombotic Research in Tromso. Institute of Clinical Medicine. University of Tromso. Tromso. NOR |
| Type de document : | Article |
| Dans : | European journal of epidemiology (vol. 26, n° 4, 2011) |
| Pagination : | 305-312 |
| Langues: | Anglais |
| Mots-clés : | Taille corporelle ; Ostéoporose ; Norvège ; Epidémiologie ; Homme ; Europe |
| Résumé : | [BDSP. Notice produite par INIST-CNRS GqR0xE7s. Diffusion soumise à autorisation]. Severe loss of body height is often a consequence of osteoporotic vertebral fractures. Osteoprotegerin (OPG) and receptor activator of nuclear factor-kB ligand (RANKL) are cytokines essential for the regulation of bone resorption. The aim of this study was to assess the relationship between the OPG/RANKL system and height loss. A total of 4,435 inhabitants from the municipality of Tromso, Norway (2,169 men and 2,266 women) were followed for 6 years. Baseline measurements included height, weight, bone mineral density, OPG, RANKL, serum parathyroid hormone and information about life-style, prevalent diseases and use of medication. Height was measured again at follow-up, and the loss of height was categorized into 4 groups :<=1,1.1-2,2.1-3,>3 cm. We found increasing height loss with increasing baseline OPG levels in both men and women (P trend=0.02 and 0.001, respectively), after adjustments for age and other con-founders. However, when the women were stratified according to menopausal status and use of hormone replacement therapy (HRT), a significant relationship was present only among postmenopausal women not using HRT (P trend=0.02). No relations between OPG and height loss were found in post-menopausal HRT-users and premenopausal women (P trend>=0.39). We conclude that height loss is positively associated with OPG in men and in postmenopausal women not using HRT. No relationship was found between RANKL and height loss. |
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