| Titre : | Lack of Association of Herpes Simplex Virus Type 2 Seropositivity With the Progression of HIV Infection in the HERS Cohort. (2011) |
| Auteurs : | Brooke-E HOOTS ; Stephen-R COLE ; Michael-G HUDGENS ; Denise-J JAMIESON ; Caroline-C KING ; Robert-S Klein ; Kenneth-H MAYER ; Anne-M ROMPALO ; Jennifer-S Smith ; Jack-D SOBEL |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 173, n° 7, 2011) |
| Pagination : | 837-844 |
| Langues: | Anglais |
| Mots-clés : | Sida ; Association ; Séropositivité ; Pronostic ; Evolution ; Herpès ; Homme ; VIH ; Epidémiologie ; Virose ; Infection ; Virus ; Rétrovirus ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS 8q8JHR0x. Diffusion soumise à autorisation]. Many studies have chronicled the "epidemiologic synergy" between human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2). HIV adversely affects the natural history of HSV-2 and results in more frequent and severe HSV-2 reactivation. Few longitudinal studies, however, have examined whether HSV-2 is associated with increased HIV plasma viral loads or decreased CD4 counts. The authors estimated the effect of HSV-2 seropositivity on HIV RNA viral load and on CD4 count over time among 777 HIV-seropositive US women not receiving suppressive HSV-2 therapy in the HIV Epidemiology Research Study (1993-2000). Linear mixed models were used to assess the effect of HSV-2 on log HIV viral load and CD4 count/mm3 prior to widespread initiation of highly active antiretroviral therapy. Coinfection with HSV-2 was not associated with HIV RNA plasma viral loads during study follow-up. There was a statistically significant association between HSV-2 seropositivity and CD4 count over time, but this difference was small and counterintuitive at an increase of 8 cells/mm3 (95% confidence interval : 2,14) per year among HSV-2-seropositive women compared with HSV-2-seronegative women. These data do not support a clinically meaningful effect of baseline HSV-2 seropositivity on the trajectories of HIV plasma viral loads or CD4 counts. |
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