| Titre : | Serum 25-Hydroxyvitamin D and Risks of Colon and Rectal Cancer in Finnish Men. (2011) |
| Auteurs : | Stephanie-J WEINSTEIN ; Demetrius ALBANES ; ASHBY (Jason) : USA. Information Management Services. Inc. Silver Spring. MD. ; HORST (Ronald-L) : USA. Heartland Assays. Inc. Ames. IA. ; . KAI YU ; VIRTAMO (Jarmo) : FIN. Department of Chronic Disease Prevention. National Institute for Health and Welfare. Helsinki. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 173, n° 5, 2011) |
| Pagination : | 499-508 |
| Langues: | Anglais |
| Mots-clés : | Sérum ; Facteur risque ; Risque ; Finlande ; Homme ; Etude prospective ; Vitamine D ; Epidémiologie ; Europe ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS o8nFR0x8. Diffusion soumise à autorisation]. Prospective investigations of circulating vitamin D concentrations suggest inverse associations with colorectal cancer risk, although inconsistencies remain and few studies have examined the impact of season. The authors conducted a prospective case-control study of 239 colon cancer cases and 192 rectal cancer cases (diagnosed in 1993-2005) and 428 controls matched on age and blood collection date within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a cohort study of Finnish male smokers. Baseline serum 25-hydroxyvitamin D (25 (OH) D) concentrations were categorized using a priori defined cutpoints of<25,25-<37.5,37.5-<50,50-<75, and>=75 nmol/L and by season-specific and season-standardized 25 (OH) D quartiles. Conditional logistic regression models yielded multivariate-adjusted odds ratios for the predefined cutpoints of 0.63,0.91,0.73,1.00 (referent), and 1.44 for colon cancer and 0.64,0.58,0.84,1.00, and 0.76 for rectal cancer, respectively (all 95% confidence intervals included 1.00). Colon cancer risks were significantly elevated for the highest season-specific and season-standardized quartiles versus the lowest quartiles (OR=2.11 (95% CI : 1.20,3.69) and OR=1.88 (95% CI : 1.07,3.28), respectively), while rectal cancer risk estimates were null. These results provide no evidence to support an inverse association between vitamin D status and colon or rectal cancer risk ; instead, they suggest a positive association for colon cancer. |
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