| Titre : | Serum 25-Hydroxyvitamin D Levels and Incident Asthma in Adults The HUNT Study. (2012) |
| Auteurs : | Xiao-Mei MAI ; CAMARGO (Carlos-Ajr) : USA. Department of Emergency Medicine. Massachusetts General Hospital. Harvard Medical School. Boston. MA. ; Arnulf LANGHAMMER ; YUE CHEN (.) : CAN. Department of Epidemiology and Community Medicine. Faculty of Medicine. University of Ottawa. Ottawa. ON. |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 176, n° 12, 2012) |
| Pagination : | 1169-1176 |
| Langues: | Anglais |
| Mots-clés : | Asthme ; Allergie ; Sérum ; Incidence ; Adulte ; Enquête cas témoin ; Epidémiologie ; Etude prospective ; Vitamine D ; Homme ; Bronchopneumopathie obstructive ; Immunopathologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS r98R0xF8. Diffusion soumise à autorisation]. The impact of low vitamin D status on asthma development is unclear. The authors investigated the relation between the baseline serum 25-hydroxyvitamin D (25 (OH) D) level and incident asthma in adults, including possible effect modification by allergy status, using allergic rhinitis as a proxy measure. A cohort of 25,616 Norwegian adults aged 19-55 years participated in 2 surveys of the Nord-Trondelag Health Study known as HUNT 2 (1995-1997) and HUNT 3 (2006-2008). Of this cohort, a nested case-control study included 584 new-onset asthma cases and 1,958 nonasthma controls whose baseline serum 25 (OH) D levels were measured. After adjustment for potential asthma risk factors, the baseline serum level of 25 (OH) D (<50 nmol/L) was not significantly associated with asthma in either women (adjusted odds ratio=0.94,95% confidence interval (CI) : 0.67,1.32) or men (adjusted odds ratio=1.47,95% CI : 0.93,2.32). In men, allergic rhinitis modified the association with the adjusted odds ratio being 0.87 (95% CI : 0.36,2.06) among men with allergic rhinitis and 2.32 (95% CI : 1.06,5.10) among men without allergic rhinitis. The serum 25 (OH) D level was not associated with incident asthma in women, regardless of allergy status. Low vitamin D status was not significantly associated with incident asthma in most adults, but it may have increased risk among men without allergy. |
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