| Titre : | Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium. (2012) |
| Auteurs : | Mitchell-J MACHIELA ; Demetrius ALBANES ; Naomi-E ALLEN ; Aurelio BARRICARTE ; H. BAS BUENO-DE-MESQUITA ; Sonja-I BERNDT ; Stephen CHANOCK ; Susan-M GAPSTUR ; Edward GIOVANNUCCI ; Christopher-A HAIMAN ; Brian-E HENDERSON ; David J. Hunter ; Eric-J JACOBS ; . JING MA ; Laurence-N KOLONEL ; Peter KRAFT ; Vittorio KROGH ; Loic LE MARCHAND ; Sara LINDSTROM ; J. MICHAEL GAZIANO ; Meir-J STAMPFER ; Victoria-L STEVENS ; Daniel-O STRAM ; Anne TJONNELAND ; Ruth TRAVIS ; Walter-C Willett |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 176, n° 12, 2012) |
| Pagination : | 1121-1129 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Risque cumulé ; Facteur associé ; Association ; Sensibilité ; Facteur risque ; Risque ; Sein ; Maladie héréditaire ; Hérédité ; Génétique ; Génome ; Homme ; Epidémiologie ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS lp9t8R0x. Diffusion soumise à autorisation]. Observational studies have found an inverse association between type 2 diabetes (T2D) and prostate cancer (PCa), and genome-wide association studies have found common variants near 3 loci associated with both diseases. The authors examined whether a genetic background that favors T2D is associated with risk of advanced PCa. Data from the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium, a genome-wide association study of 2,782 advanced PCa cases and 4,458 controls, were used to evaluate whether individual single nucleotide polymorphisms or aggregations of these 36 T2D susceptibility loci are associated with PCa. Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNR1B, FTO, and HNF1B) were nominally associated with PCa (P<0.05) ; the association for single nucleotide polymorphism rs757210 at the HNF1B locus was significant when multiple comparisons were accounted for (adjusted P=0.001). |
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