Titre :
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Incidence of Creutzfeldt-Jakob disease in Taiwan : a prospective 10-year surveillance. (2010)
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Auteurs :
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Chien-Jung LU ;
CHEN (Shun-Sheng) : TWN. Department of Neurology. Chang Gung Memorial Hospital. Kaohsiung Medical Center. School of Medicine. Chang Gung University. Kaohsiung County. ;
. YU SUN ;
Department of Neurology. En Chu Kong Hospital. Taipei. TWN
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 25, n° 5, 2010)
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Pagination :
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341-347
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Langues:
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Anglais
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Mots-clés :
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Incidence
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Taiwan
;
Long terme
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Surveillance
;
Etude prospective
;
Epidémiologie
;
Ethnie
;
Chine
;
Homme
;
Prion
;
Infection
;
Asie
;
Maladie dégénérative
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Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xn99FF. Diffusion soumise à autorisation]. This study was performed to estimate the incidence of Creutzfeldt-Jakob Disease (CJD) in Taiwan from 1998 to 2007. Suspected cases of CJD were reported to the Taiwan Creutzfeldt-Jakob Disease Surveillance Unit, a nationwide, hospital-based case report system initiated since 1996 to prospectively conduct a CJD epidemiological study. Consecutive patients who met the diagnostic criteria recommended by the World Health Organization were enrolled. The clinical information of each suspected case was collected and case ascertainment was performed by an expert committee. A total of 123 sporadic CJD were identified without any iatrogenic or new variant CJD cases. The overall annual incidence rate (95% CI) was 0.55 (0.46-0.65) cases per million person-year. There was no statistically significant difference between the calendar year of disease onset (P=0.97). The incidence rates were not significantly different between women and men (P=0.63). Age was the main factor for the risk of CJD (P<0.0001). Age-specific incidence rate increased after the age of 40 years with the peak being in the 70-79 years age group. Our data showed low annual incidence rate and high frequency of methionine homozygous prion protein genotype of sCJD in Taiwan. This report provided important epidemiological data on ethnic Chinese.
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