Titre : | Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis. (2010) |
Auteurs : | . FANG FANG ; Kelli-D ALLEN ; Freya KAMEL ; KELLER (Jean) : USA. Westat. Durham. NC. ; Lydia-C KWEE ; Eugene-Z ODDONE ; Dale-P SANDLER ; Silke SCHMIDT ; UMBACH (David-M) : USA. Biostatistics Branch. National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health and Human Services. Research Triangle Park. NC. ; WATSON (Mary) : USA. Social and Scientific Systems Inc. Durham. NC. ; . WEIMIN YE ; Center for Human Genetics. Department of Medicine. Duke University Medical Center. Durham. NC. USA ; Epidemiology Research and Information Center. Durham Va Medical Center. Durham. NC. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 171, n° 10, 2010) |
Pagination : | 1126-1133 |
Langues: | Anglais |
Mots-clés : | Maladie Charcot ; Facteur associé ; Association ; Sang ; Facteur risque ; Os ; Epidémiologie ; Maladie dégénérative ; Risque relatif |
Résumé : | [BDSP. Notice produite par INIST-CNRS GFlAR0xr. Diffusion soumise à autorisation]. The authors conducted a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this association of bone turnover and genetic factors related to lead toxicokinetics. Blood lead, plasma biomarkers of bone formation (procollagen type 1 amino-terminal peptide (PINP)) and resorption (C-terminal telopeptides of type 1 collagen (CTX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured. Odds ratios and 95% confidence intervals for the association of blood lead with ALS were estimated with unconditional logistic regression after adjustment for age and bone turnover. Blood lead levels were higher among cases compared with controls (P |