| Titre : | Intake of Polyunsaturated Fatty Acids and Distal Large Bowel Cancer Risk in Whites and African Americans. (2010) |
| Auteurs : | Sangmi KIM ; Joseph GALANKO ; Christopher Martin ; Dale-P SANDLER ; Robert-S SANDLER |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 9, 2010) |
| Pagination : | 969-979 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Intestin ; Facteur risque ; Risque ; Homme ; Acide gras ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS H8pR0xkp. Diffusion soumise à autorisation]. Long-chain oméga-3 polyunsaturated fatty acids (PUFAs) may have antineoplastic properties in the colon. The authors examined the association between intakes of different PUFAs and distal large bowel cancer in a population-based case-control study of 1,503 whites (716 cases ; 787 controls) and 369 African Americans (213 cases ; 156 controls) in North Carolina (2001-2006). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals for distal large bowel cancer risk in relation to quartiles of PUFA intake. Increased consumption of long-chain oméga-3 PUFAs was associated with reduced risk of distal large bowel cancer in whites (multivariable odds ratios=0.88 (95% confidence interval (CI) : 0.63,1.22), 0.69 (95% CI : 0.49,0.98), and 0.49 (95% CI : 0.34,0.71) for second, third, and highest vs. lowest quartile) (Ptrend<0.01). Intake of individual eicosapentaenoic acids and docosahexaenoic acids was inversely related to distal large bowel cancer risk, whereas the ratio of oméga-6 to long-chain oméga-3 PUFAs was associated with increased risk of distal large bowel cancer in whites, but not among African Americans (Pinteraction<0.05). Study results support the hypothesis that long-chain oméga-3 PUFAs have beneficial effects in colorectal carcinogenesis. Whether or not the possible benefit of long-chain oméga-3 PUFAs varies by race warrants further evaluation. |
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