| Titre : | Associations of Toenail Selenium Levels With Inflammatory Biomarkers of Fibrinogen, High-Sensitivity C-Reactive Protein, and Interleukin-6 : The CARDIA Trace Element Study. (2010) |
| Auteurs : | . PENGCHENG XUN ; Martha-L DAVIGLUS ; JACOBS (David-Rjr) : USA. Department of Epidemiology. School of Public Health. University of Minnesota. Minneapolis. MN. ; . KA HE ; . KIANG LIU ; Jsteven MORRIS ; STEVENS (June) : USA. Research Reactor Center. University of Missouri-Columbia. Columbia. MO. ; Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina. Chapel Hill. NC. USA ; Department of Nutrition. Gillings School of Global Public Health and School of Medicine. University of North Carolina. Chapel Hill. NC. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 171, n° 7, 2010) |
| Pagination : | 793-800 |
| Langues: | Anglais |
| Mots-clés : | Association ; Sélénium ; Inflammation ; Sensibilité ; Ongle ; Oligoélément |
| Résumé : | [BDSP. Notice produite par INIST-CNRS qR0xH8Hq. Diffusion soumise à autorisation]. The authors examined the associations of toenail selenium levels with blood concentrations of fibrinogen, high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in an 18-year follow-up study comprising 4,032 Americans aged 20-32 years at baseline (1987) from the Coronary Artery Risk Development in Young Adults (CARDIA) Trace Element Study. Toenail samples were collected in 1987, and selenium concentrations were measured by means of instrumental neutron-activation analysis. Fibrinogen level was analyzed in 1990,1992, and 2005 ; hs-CRP was assessed in 1992,2000, and 2005 ; and IL-6 was measured in 2005. After adjustment for potential confounders, no statistically significant associations between toenail selenium levels and any of the 3 inflammatory biomarkers were documented. Comparing the highest quintile of toenail selenium level with the lowest, odds ratios for elevated levels of fibrinogen (>460 mg/mL), hs-CRP (>3 mug/mL), and IL-6 (>3.395 pg/mL, 80th percentile) were 1.03 (95% confidence interval (CI) : 0.77,1.38 ; Pfor trend=0.76), 1.02 (95% CI : 0.83,1.27 ; P for trend=0.92), and 0.98 (95% CI : 0.71,1.36 ; Pfor trend=0.82), respectively. Gender, race/ethnicity, smoking status, and selenium supplementation did not appreciably modify these results. This study found no associations between toenail selenium and inflammation as measured by fibrinogen, hs-CRP, and IL-6. |
Service Documentation EHESP
Me connecter
PORTAIL DOCUMENTAIRE
École des hautes études en santé publique
Catalogue
Multi-bases
Accueil
Sélection de la langue
Adresse
Service Documentation EHESPBibliothèque Rennes Avenue du Professeur Léon Bernard – CS 74312 – 35043 Rennes Cedex Bibliothèque MSSH Paris 20 avenue George Sand - 93210 La Plaine Saint-Denis
France
Bibliothèque Rennes : 02 99 02 29 50 Bibliothèque MSSH Paris : 02 99 02 24 50
contact